Betamethasone cancer
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Betamethasone cancer
Betamethasone topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis a skin disease in which red, scaly patches form on some areas of the body and eczema a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes. Betamethasone is in a class of medications called corticosteroids.
It works by activating natural substances in the skin to reduce swelling, redness, and itching. Betamethasone comes in ointment, cream, lotion, gel, and aerosol spray in various strengths for use on the skin and as a foam to apply to the scalp.
It is usually applied once or twice daily. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Use betamethasone exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Do not apply it to other areas of your body or use it to treat other skin conditions unless directed to do so by your doctor. Your skin condition should improve during the first 2 weeks of your treatment. Call your doctor if your symptoms do not improve during this time. To use betamethasone topical, apply a small amount of ointment, cream, solution, gel, or lotion to cover the affected area of skin with a thin even film and rub it in gently.
To use the foam on your scalp, part your hair, apply a small amount of the medicine on the affected area, and rub it in gently. You may wash your hair as usual but not right after applying the medicine. Betamethasone foam may catch fire. Stay away from open fire, flames, and do not smoke while you are applying betamethasone foam, and for a short time afterward.
This medication is only for use on the skin. Do not let betamethasone topical get into your eyes or mouth and do not swallow it. Avoid use in the genital and rectal areas and in skin creases and armpits unless directed by your doctor.
If you are using betamethasone on a child's diaper area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.
Do not apply other skin preparations or products on the treated area without talking with your doctor. Do not wrap or bandage the treated area unless your doctor tells you that you should. Call your doctor if the treated area gets worse or if burning, swelling, redness, or oozing of pus develops. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Apply the missed dose as soon as you remember it.
However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Betamethasone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: burning, itching, irritation, stinging, redness, or dryness of the skin acne unwanted hair growth skin color changes bruising or shiny skin tiny red bumps or rash around the mouth small white or red bumps on the skin.
If you experience any of the following symptoms, call your doctor immediately: severe rash redness, swelling, or other signs of skin infection in the place where you applied betamethasone. Children who use betamethasone topical may have an increased risk of side effects including slowed growth and delayed weight gain. Talk to your child's doctor about the risks of applying this medication to your child's skin.
Betamethasone topical may cause other side effects. Call your doctor if you have any unusual problems while using this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom.
Do not freeze it.. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
Web Site. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. If someone swallows betamethasone topical, call your local poison control center at If the victim has collapsed or is not breathing, call local emergency services at Keep all appointments with your doctor and the laboratory.
Your doctor may order certain lab tests to check your body's response to betamethasone. Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice.
Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. All rights reserved. Betamethasone Topical bay ta meth' a sone. Drgwhy Betamethasone topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis a skin disease in which red, scaly patches form on some areas of the body and eczema a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes.
Drghow Betamethasone comes in ointment, cream, lotion, gel, and aerosol spray in various strengths for use on the skin and as a foam to apply to the scalp. Drgotheruses This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before using betamethasone, tell your doctor and pharmacist if you are allergic to betamethasone, any other medications, or any of the ingredients in betamethasone topical products. Ask your pharmacist for a list of the ingredients. Be sure to mention the following: other corticosteroid medications and other topical medications.
If you become pregnant while using betamethasone topical, call your doctor immediately. Drgmisseddose Apply the missed dose as soon as you remember it. Drgsideeffects Drgadveff Betamethasone may cause side effects. Drgsevereadveff If you experience any of the following symptoms, call your doctor immediately: severe rash redness, swelling, or other signs of skin infection in the place where you applied betamethasone Children who use betamethasone topical may have an increased risk of side effects including slowed growth and delayed weight gain.
Drgstorage Keep this medication in the container it came in, tightly closed, and out of reach of children. Web Site Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Drgoverdose If someone swallows betamethasone topical, call your local poison control center at Drgotherinfo Keep all appointments with your doctor and the laboratory.
Generic alternatives may be available. Selected Revisions: February 15,
❾-50%}Markey study: Betamethasone could improve outcomes for prostate cancer radiation therapy | UKNow
Radiation therapy is important because it controls the growth of prostate cancer, but it comes with a variety of unwanted side effects. These include injury to normal tissues. Around Food and Drug Administration- approved drugs were screened by the team. They were analysing the drugs for properties including:. Betamethasone is a corticosteroid approved for treating inflammation and cancer of the hematopoietic system.
It came in the top five drugs tested, possessing all of the desired properties. The research was published in the International Journal of Molecular Sciences.
Save my name, email, and website in this browser for the next time I comment. UK HealthCare. Campus News. Since the molecular targets of these strategies are most likely different, additive or synergic effects are envisaged.
Abstract Tumor resistance to traditional cancer treatments poses an important challenge to modern science. Potential adverse effects related to the neurotoxicity of betamethasone and the intrathecal injection procedure, such as headache, back pain, low back pain, numbness in the limbs, sensory weakness, motor weakness, gait disturbance, and recto-bladder dysfunction, were assessed weekly.
The site of pain, cancer origin, bone metastasis, morphine dose, and the number of intrathecal betamethasone injections are shown in Table 1. Despite having been given anti-cancer therapies and systemic analgesic pharmacotherapies, the patients had severe and persistent pain in the low back, pelvis, perineum, or lower limb region. Before treatment, half of the patients were given small doses of morphine, because of their conditions or adverse effects such as nausea or somnolence.
Betamethasone was injected in the intrathecal space one to four times during the 4-week study period, depending on the patient's physical and mental condition. In four patients with bone metastasis in the lumbar vertebrae, the intrathecal approach was chosen to avoid the metastatic region. Injection failure, paresthesia, bleeding, and other technical difficulties were not seen in any of the patients. During the study period, three patients dropped out; of these three patients, two were transferred to another hospital, and one patient died.
Abnormal symptoms and signs related to sensory and motor nerve dysfunction were not seen. Hypotension, bradycardia, headache, and recto-bladder dysfunction were not observed in the hour after betamethasone injection. Analgesic effects during the first week of treatment. Daily pain intensity was assessed by the patients themselves using the numerical pain score PS.
Long-lasting analgesia was maintained after immediate analgesia in many of the patients. During the first week of treatment, five patients No. Good and long-lasting pain relief for 4 weeks was obtained in five of seven patients who completed the study. The rescue morphine dose had to be increased in three of the five patients without increasing the other analgesics, whereas two patients No. In patients with satisfactory pain relief, uncomfortable symptoms improved, and activities of daily living gradually recovered.
Some patients could walk better; however, if vertebral bone stability could not be maintained, the patients had pain when walking and standing. Adverse effects related to neurotoxicity of intrathecal betamethasone, such as sensory and motor dysfunctions, did not occur in any of the patients Table 3.
Adverse effects during treatment. Symptoms related to neurotoxicity of intrathecal betamethasone and other adverse effects were not found in any of the patients during the 4-week study period. Motor nerve functions such as motor weakness and gait disturbance improved in some patients.
We have previously reported on the achievement of long-lasting analgesia using intrathecal betamethasone with saline in three cancer patients. With intrathecal betamethasone treatment, none of the patients developed adverse effects such as neurological dysfunction, and about a half of the patients achieved sufficient analgesia against intractable pain. In the current study, we did not use a controlled design, as intrathecal injections of clonidine, midazolam, or opioids, which would be used in the control group, are often associated with uncomfortable adverse effects.
Thus, it would be difficult to perform a controlled study of intrathecal analgesia in terminally ill patients. There are several arguments concerning the safety of intrathecal injection of steroids. Complications such as arachnoiditis and meningitis have been reported. However, the safety of intrathecal glucocorticoids has been advocated in some clinical and experimental studies. It is also important information to carry with you in case of emergencies. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. All rights reserved. Betamethasone Topical bay ta meth' a sone.
Drgwhy Betamethasone topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis a skin disease in which red, scaly patches form on some areas of the body and eczema a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes.
Drghow Betamethasone comes in ointment, cream, lotion, gel, and aerosol spray in various strengths for use on the skin and as a foam to apply to the scalp.
Drgotheruses This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Before using betamethasone, tell your doctor and pharmacist if you are allergic to betamethasone, any other medications, or any of the ingredients in betamethasone topical products.
Ask your pharmacist for a list of the ingredients. Be sure to mention the following: other corticosteroid medications and other topical medications. If you become pregnant while using betamethasone topical, call your doctor immediately.
The lab study led by Luksana Chaiswing, Ph. Prostate cancer is the second leading cause of cancer deaths among men in the U. While radiation therapy is important to control the growth of prostate cancer, it presents a significant risk of increasing unwanted side effects, including injury to normal tissues.
The team screened around Food and Drug Administration-approved drugs for properties including protecting non-cancer cells against radiation therapy induced cytotoxicity, killing prostate cancer cells and increasing hydrogen peroxide levels in both cancer and non-cancer cells. Betamethasone, a corticosteroid that is approved for treatment of inflammation and cancer of the hematopoietic system, was one of the top five drugs with all of the desired properties.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The University of Kentucky is increasingly the first choice for students, faculty and staff to pursue their passions and their professional goals. Accolades and honors are great. But they are more important for what they represent: the idea that creating a community of belonging and commitment to excellence is how we honor our mission to be not simply the University of Kentucky, but the University for Kentucky.
By Elizabeth Chapin Aug. Share This facebook twitter email. Professional News. UK HealthCare. Campus News.
Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3. It is used to treat some types of psoriasis. It is used to treat skin irritation. It is used to treat skin rashes. It is used to treat scalp irritation. It may. Intrathecal betamethasone may induce long-lasting analgesia without adverse effects. As a result, intrathecal betamethasone may be able to improve activities of. Common steroid betamethasone could be used to reduce unwanted side effects of radiation treatments for prostate cancer. It works by activating natural substances in the skin to reduce swelling, redness, and itching. Drghow. Betamethasone comes in ointment, cream, lotion, gel, and. Google Scholar. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Thus, angiogenesis inhibition is an important emerging cancer treatment. Given our findings, the mechanism of the analgesic effects of intrathecal glucocorticoid should be studied in greater depth in the future.Taguchi, K. Oishi, S. Sakamoto, K. Sufficient analgesia for cancer pain is sometimes difficult to achieve with conventional treatments. We aimed at investigating the analgesic efficacy and safety of intrathecal betamethasone in patients with uncontrollable cancer pain.
Betamethasone 1 mg mixed with saline was injected into the lumbar intrathecal space once a week in 10 patients with persistent cancer pain in the lower half of the body. During the 4-week study period, the analgesic efficacy and adverse effects related to intrathecal betamethasone were observed.
In almost all of the patients, not only pain, but also uncomfortable symptoms were improved. Adverse effects related to neurotoxicity of intrathecal betamethasone, such as sensory and motor dysfunctions, were not observed in any patients. When conventional cancer pain treatments are not successful, intrathecal betamethasone may be useful, as it probably induces long-lasting analgesia without adverse effects and improves activities of daily living, especially in patients with vertebral bone metastases.
Despite advances in pain management, cancer pain is still often intractable. It is thought that the effects of glucocorticoids are mediated by their anti-inflammatory or immunosuppressive actions. Recently, evidence for the involvement of various neurotransmitters and pain modulators in pain perception has been reported, 4—6 and treatments that target this aspect of the pathogenesis of pain are being developed.
The intrathecal use of glucocorticoid may be effective for the treatment of inflammatory or neuro-injury associated pain in the spinal cord and roots, as it has an inhibitory action on prostaglandins and other algogenic substances.
However, adverse effects related to neurotoxicity of intrathecal glucocorticoid have been reported. After obtaining the patient's medical history and present illness, the vital signs were taken and a neurological examination was performed. Inclusion criteria consisted of the presence of advanced cancer, cancer pain located in the lower half of the body, and uncontrollable pain despite conventional analgesic therapies.
Ten patients who met the inclusion criteria were enrolled, and written informed consent was obtained from all of them. During the 4-week study period, intrathecal betamethasone was scheduled to be given once a week. The dose of slow-release oral morphine was to remain unchanged during the treatment, but rescue doses of oral morphine and NSAIDs, which were received 0—3 times a day before the treatment, could be given based on the patients' needs.
In the lateral decubitus position, a gauge pencil-point spinal needle was inserted through the interlaminar space in the lumber vertebrae to avoid the metastatic region. Betamethasone solution Rinderon Injection, Shionogi Pharmaceuticals, Osaka, Japan , including 2 mg of betamethasone, 0.
The betamethasone dose was 1 mg 0. Immediately after intrathecal injection of betamethasone, the acute analgesic effect was examined at 5, 10, 20, and 30 min using the visual analogue scale VAS. The development of abnormal neurological signs and symptoms was observed for 1 h.
We used a PS as a pain relief scale after the treatment, considering the variability and multiple dimensions of cancer pain during the course of the disease. Potential adverse effects related to the neurotoxicity of betamethasone and the intrathecal injection procedure, such as headache, back pain, low back pain, numbness in the limbs, sensory weakness, motor weakness, gait disturbance, and recto-bladder dysfunction, were assessed weekly. The site of pain, cancer origin, bone metastasis, morphine dose, and the number of intrathecal betamethasone injections are shown in Table 1.
Despite having been given anti-cancer therapies and systemic analgesic pharmacotherapies, the patients had severe and persistent pain in the low back, pelvis, perineum, or lower limb region. Before treatment, half of the patients were given small doses of morphine, because of their conditions or adverse effects such as nausea or somnolence. Betamethasone was injected in the intrathecal space one to four times during the 4-week study period, depending on the patient's physical and mental condition.
In four patients with bone metastasis in the lumbar vertebrae, the intrathecal approach was chosen to avoid the metastatic region. Injection failure, paresthesia, bleeding, and other technical difficulties were not seen in any of the patients.
During the study period, three patients dropped out; of these three patients, two were transferred to another hospital, and one patient died. Abnormal symptoms and signs related to sensory and motor nerve dysfunction were not seen. Hypotension, bradycardia, headache, and recto-bladder dysfunction were not observed in the hour after betamethasone injection.
Analgesic effects during the first week of treatment. Daily pain intensity was assessed by the patients themselves using the numerical pain score PS. Long-lasting analgesia was maintained after immediate analgesia in many of the patients. During the first week of treatment, five patients No.
Good and long-lasting pain relief for 4 weeks was obtained in five of seven patients who completed the study. The rescue morphine dose had to be increased in three of the five patients without increasing the other analgesics, whereas two patients No. In patients with satisfactory pain relief, uncomfortable symptoms improved, and activities of daily living gradually recovered. Some patients could walk better; however, if vertebral bone stability could not be maintained, the patients had pain when walking and standing.
Adverse effects related to neurotoxicity of intrathecal betamethasone, such as sensory and motor dysfunctions, did not occur in any of the patients Table 3. Adverse effects during treatment. Symptoms related to neurotoxicity of intrathecal betamethasone and other adverse effects were not found in any of the patients during the 4-week study period.
Motor nerve functions such as motor weakness and gait disturbance improved in some patients. We have previously reported on the achievement of long-lasting analgesia using intrathecal betamethasone with saline in three cancer patients. With intrathecal betamethasone treatment, none of the patients developed adverse effects such as neurological dysfunction, and about a half of the patients achieved sufficient analgesia against intractable pain.
In the current study, we did not use a controlled design, as intrathecal injections of clonidine, midazolam, or opioids, which would be used in the control group, are often associated with uncomfortable adverse effects. Thus, it would be difficult to perform a controlled study of intrathecal analgesia in terminally ill patients.
There are several arguments concerning the safety of intrathecal injection of steroids. Complications such as arachnoiditis and meningitis have been reported. However, the safety of intrathecal glucocorticoids has been advocated in some clinical and experimental studies. In the clinical study by Kotani and colleagues, 12 there were no complications in 89 patients with postherpetic neuralgia who received four doses of intrathecal methylprednisolone acetate 60 mg containing propylene glycol.
Langmayr and colleagues 13 indicated that, after lumbar disc surgery, intrathecal betamethasone provided significant pain reduction without any disadvantageous effects. Latham and colleagues 14 showed in sheep that repeated intrathecal administration of 5. However, large doses of betamethasone, such as Furthermore, it has been found that intrathecal triamcinolone diacetate containing polyethylene glycol did not induce spinal neurotoxicity in rat model.
We chose betamethasone as the glucocorticoid for intrathecal injection because of its water solubility, the presence of small dose additives in the solution, its safety in animal studies, and the fact that the intrathecal use of betamethasone is recommended for meningeal leukaemia, cerebrospinal meningitis, malignant lymphoma, etc.
To avoid possible neural damage, we used a small dose 1 mg and volume 0. The 0. Additionally, it has been reported that intrathecal bisulphite can reduce the neurotoxic damage induced by the intrathecal injection of local anaesthetic chloroprocaine.
In the current study, clinical neurotoxicity was not seen after intrathecal betamethasone injection. On the contrary, neurological symptoms such as motor weakness and gait disturbance improved, and activities of daily living gradually recovered in many patients. Nevertheless, the sample size of this study 10 patients is too small to conclusively demonstrate the safety of intrathecal betamethasone; for this, a larger study is needed. Glucocorticoids have multipurpose use, offering symptomatic relief in the management of patients with cancer pain.
Principally, the analgesic effect of glucocorticoids is assumed to occur in inflammatory conditions. Recently, the analgesic effects of intrathecal steroids have been observed in both human and animal studies. It is thought that the long-lasting analgesia that results from the intrathecal injection of betamethasone is achieved through a decrease in the inflammatory reactions in the injured nerves and a reduction in algogenic substances such as prostaglandins, glutamate, and substance P in the spinal cord.
The suppression of spinal glial activation and the inhibition of inflammatory cells and cytokines may accelerate analgesic effects. The effects of steroids are not expected to be immediate, as the changes in gene expression and synthesis of proteins take several hours. Anti-inflammatory effects of glucocorticoids are induced by the inhibition of phospholipase A2 resulting from lipocortin production through the fundamental steroid pharmacology. However, this mechanism for the analgesic effect of intrathecal glucocorticoid does not explain the immediate analgesia that was seen.
This rapid effect may be transmitted by specific membrane-bound receptors. Given our findings, the mechanism of the analgesic effects of intrathecal glucocorticoid should be studied in greater depth in the future. Opioids are widely used in the management of cancer pain, but sufficient pain relief without side-effects is sometimes difficult to obtain. Although intrathecal or epidural opioid injections may be a good option for cancer pain treatment, the patients develop side effects similar to oral opioids, and a catheter must be implanted for continuous opioid injection.
Oral glucocorticoids are used palliatively for cancer pain treatment, especially in patients with bone metastases. Therefore, certain types of uncontrollable cancer pain can be better treated with intrathecal betamethasone, especially in patients with vertebral metastases whose pain is frequently difficult to control.
In contrast to epidural procedures, the intrathecal technique is easy and safe to perform in the lumbar region. Therefore, the intrathecal injection of betamethasone has a technical advantage over other anaesthetic procedures for the management of cancer pain.
When conventional treatments for cancer pain are not successful, intrathecal injection of small-dose betamethasone may be a useful approach, especially in patients with vertebral bone metastases. Intrathecal betamethasone may induce long-lasting analgesia without adverse effects. As a result, intrathecal betamethasone may be able to improve activities of daily living and quality of life in patients with cancer pain.
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Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. Intrathecal betamethasone for cancer pain in the lower half of the body: a study of its analgesic efficacy and safety.
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