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Arrives as quickly as the next working day in discreet packaging. Our team of doctors and pharmacists, and our support staff, are all UK-based. We're on hand to offer free support and advice by email and telephone Mon - Fri - Are you looking to buy Differin gel - one of the best, and most popular, breakout-busting topical acne solutions?

The active ingredient of Differin is adapalene, a form of vitamin A, which reduces the growth of keratin skin cells that would normally act to block pores in acne vulgaris. Additionally, adapalene increases the turnover of surface skin cells, aiding the natural exfoliation of the skin. These dual actions help to clear acne and leave skin looking clear and oil-free. This treatment requires an online consultation for review by our medical team.

The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective. Differin Cream and Gel are both prescription acne treatments that are applied directly to the skin, making Differin a great choice for people who cannot or who do not wish to take oral antibiotics.

The active ingredient Adalpalene is effective at reducing inflammation helping to improve the appearance of blackheads, whiteheads, and pustules on the skin. Differin once daily Cream and Gel are manufactured by Galderma and are available in gram tubes for mild to moderate acute acne. Most people will notice an improvement to their skin in just a few weeks, however, Differin must be used daily for a full 3 months.

Differin can be combined with a topical or oral antibiotic for more severe acne. The active ingredient in Differin, Adapalene, is a form of vitamin A and it works to reduce the growth of keratin surface skin cells that can block pores. Sebum is a natural, oily substance produced by glands just under the surface of the skin called sebaceous glands, needed to keep the skin smooth and supple.

Sufferers of acne often produce too much sebum, which can mix with the dead keratin skin cells and cause the pores to become blocked. Blocked pores can then lead to the formation of spots, blackheads comedones and whiteheads. Applying Differin 0. This will result in a reduction of inflammation, whiteheads, comedones and spots. Differin 0. This action will help keep pores unblocked, thus reducing the formation of spots and blackheads. Acne is a very common skin complaint that can affect individual people differently, meaning that some people will find certain treatments more effective than others.

It is recommended that if you do suffer from acne you start off by trying over the counter treatments. These treatments include:. If you have tried over the counter treatments and these have not been effective, you should speak to your GP about further prescription-only options.

For details of all our acne treatments please take a look at our Advice for Acne page. If you'd like to learn more about different acne treatments, read our Adapalene Vs Tretinoin comparison page. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines:. Improvement should be seen after a few weeks.

You may use cosmetics and moisturisers whilst you are using Differin cream however you should wait for it to be fully absorbed into the skin before applying anything else. Differin has a drying effect on the skin so it is important to try to ensure that any toiletries containing alcohol or other skin-drying ingredients are not used.

Like all topical applications, there is the potential that you may be allergic to Differin. We recommend you do a spot test before commencing treatment. See our Differin side effects page for more information and make sure to read the Patient Information Leaflet enclosed with your medicines for a full list of side effects, before applying. It is usually well-tolerated and gets positive ratings from patients who review Differin. If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately.

Please log in to your online account and message one of our healthcare professionals or alternatively call us on Yes, we understand that sometimes you want to get your acne treatment as soon as possible.

If ordered before 4pm Monday to Friday, our doctors will review your consultation for Differin the same day. If it is approved your order is can be delivered as quickly as the next day. Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Differin online.

Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy. Scott is one of the two founders of The Independent Pharmacy.

He is a registered pharmacist and the registered manager of our service with the CQC. Or browse all treatments or conditions. Calculating delivery estimate. Free support and advice We're on hand to offer free support and advice by email and telephone Mon - Fri - Differin - Adapalene Acne Treatment Are you looking to buy Differin gel - one of the best, and most popular, breakout-busting topical acne solutions? Consultation required? Active ingredient Adapalene Strength 0. Differin - Important Information.

What is Differin and what is it used for? How Differin gel works The active ingredient in Differin, Adapalene, is a form of vitamin A and it works to reduce the growth of keratin surface skin cells that can block pores.

Alternatives to Differin Acne is a very common skin complaint that can affect individual people differently, meaning that some people will find certain treatments more effective than others. These treatments include: Acnecide Gel Acnecide Daily Cleanser Cetaphil Daily Cleanser If you have tried over the counter treatments and these have not been effective, you should speak to your GP about further prescription-only options.

Sources Differin 0. Differin Warnings Do not use this medicine on areas where you have cuts or scrapes or if you have a skin condition called eczema. Avoid contact with the eyes, mouth or nostrils, and avoid other very sensitive areas of the body.

If accidental contact does occur, immediately wash with warm water. Avoid exposure to strong sunlight and artificial UV light. If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor. You may be asked to use the gel less often or to stop using it for a short time. Talk to your doctor or pharmacist if you are not sure. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines: Other acne products containing benzoyl peroxide, erythromycin or clindamycin may be used with Differin but they must be applied in the morning and Differin at night.

Cosmetics may be used but they must not cause blackheads or dry the skin. Pregnancy and breastfeeding Differin should not be used during pregnancy. If you fall pregnant while using Differin, the treatment must be discontinued and you should inform your doctor as soon as possible for a further follow-up.

Apply a small amount to cover the affected areas using clean fingertips and rub in lightly. At the start of treatment with Differin, if it is used correctly it will produce effects similar to that of mild sunburn including mild itching, redness and warmth. This is normal and should subside. Differin ingredients Differin contains the active ingredient: adapalene 0.

Differin side effects Like all topical applications, there is the potential that you may be allergic to Differin. Fast delivery - We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.

Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service. Still unsure about this treatment? Start Assessment.

Related Treatments for Acne. How it works. Find the ideal treatment for your condition We stock over medicines to treat over 83 conditions. Complete a short online consultation Your answers will be reviewed by a qualified healthcare professsional. Your order will be delivered as soon as the next working day. You can always easily re-order in a couple of clicks. Authored by. Reviewed by. Need something else? We stock treatments for 83 conditions. Search for a condition or treatment. Removing dead skin cells from the surface of the skin.

Burning, stinging or tingling feeling, dry skin, itching or redness, a rash.

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Cunliffe, M. Poncet, C. Loesche, M. Five comparative studies met these criteria. Adapalene demonstrated equivalent efficacy to tretinoin in terms of reducing total lesion count. Adapalene demonstrated more rapid efficacy, as evidenced by a significant difference in the reduction of inflammatory and total lesions at week 1.

Adapalene also demonstrated considerably greater local tolerability at all evaluation periods. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:. Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

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Volume Journal Article. Cunliffe , W. Oxford Academic. Google Scholar. Laboratoires Galderma, Levallois Perret, France.

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Adapalene: a new topical retinoid for acne | SpringerLink

Poncet, C.

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Article Navigation. Close mobile search navigation Article Navigation. Volume Journal Article. Cunliffe , W. Oxford Academic. Google Scholar. Laboratoires Galderma, Levallois Perret, France. Cite Cite W. Select Format Select format. Permissions Icon Permissions. Issue Section:.

You do not currently have access to this article. Download all slides. Sign in Get help with access. Get help with access Institutional access Access to content on Oxford Academic is often provided through institutional subscriptions and purchases.

If you are a member of an institution with an active account, you may be able to access content in one of the following ways: IP based access Typically, access is provided across an institutional network to a range of IP addresses. Sign in through your institution Choose this option to get remote access when outside your institution.

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Viewing your signed in accounts Click the account icon in the top right to: View your signed in personal account and access account management features. View the institutional accounts that are providing access. Signed in but can't access content Oxford Academic is home to a wide variety of products. It is supplied in plastic tube with a plastic cap containing 3g, 5g, 30 g and 50g of cream or 5g, 30g and 50g of gel.

Excipients with known effect. Methyl hydroxybenzoate, propyl hydroxybenzoate. For the full list of excipients see Section 6. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes. The affected areas should be dry before application. Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use.

Cutaneous safety of Differin topical cream has been demonstrated in patients for up to 12 weeks of treatment. Since it is customary to alternate therapies in the treatment of acne vulgaris, it is recommended that the physician assess continued treatment of the patient with Differin topical cream after 3 months of use.

If product enters the eye, wash immediately with warm water. Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body.

If a reaction suggesting severe irritation occurs, discontinue use of the medication. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether. If patients use cosmetics, these should be noncomedogenic and nonastringent. Only oil free moisturisers should be used to relieve dry facial skin. Because Differin Topical cream may cause some irritation, it is possible that simultaneous use of abrasive cleansers, astringents or strong drying agents or irritant products may cause additive irritant effects.

Whilst short-term studies have shown no phototoxic to photoallergic potential of adapalene, small numbers of reactions consistent with phototoxicity were reported in clinical studies.

The safety of using adapalene during long or repeated exposures to sunlight or UV radiation has not been established in animals or humans. Exposure to sunlight or UV irradiation including sunlamps should be avoided during treatment with adapalene. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Efficacy and safety in the treatment of severe pustular or deep cystic acne acne conglobata have not been studied.

Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed. Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied. Effects on laboratory tests. There are no known interactions with other medications which might be used topically and concurrently with Differin Topical Cream; however other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene.

Exposure of adapalene to other topical antiacne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation. Absorption of adapalene through human skin is low see Section 5. Differin topical cream has potential for local irritation and it is possible that concomitant use of peeling agents, astringents or irritant products may produce additive irritant effects.

Effects on fertility. In addition the incidences of various skeletal variations were increased at lower oral doses in rats. Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment.

In case of unexpected pregnancy, treatment should be discontinued. It is not known whether adapalene is excreted in human milk. Therefore, the preparation should be used with caution in nursing mothers, and only on areas away from the chest. Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding.

The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration. A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application. Local adverse events may persist despite cessation of therapy. No systemic reactions have been attributed to the application of the cream to date. The allergic potential of adapalene has not been established.

See Table 1. Postmarketing data. Differin Cream 0. The gel formulation was first marketed in France in September The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation.

Body as a whole. Immune system disorders. Skin and subcutaneous tissue disorders. These events often spontaneously resolve upon adaptation to therapy regimen.

Reporting suspected adverse effects. Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product.

Healthcare professionals are asked to report any suspected adverse reactions at www. Differin Topical cream is intended for topical use only. If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur. Differin topical cream is not to be taken orally.

Unless the amount accidentally ingested is small, an appropriate method of gastric emptying should be considered. For information on the management of overdose, contact the Poisons Information Centre on Australia. Mechanism of action. Adapalene is a chemically stable compound with retinoid-like pharmacological activity. Biochemical and pharmacological profile studies have demonstrated that adapalene is a potent modulator of cellular differentiation, keratinisation and inflammatory processes all of which represent important features in the pathology of acne vulgaris.

Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but unlike tretinoin, does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, current evidence suggests that topical adapalene normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Adapalene inhibits the chemotactic directional and chemokinetic random responses of human polymorphonuclear leucocytes in in vitro assay models. It also inhibits the metabolism of arachidonic acid by lipoxidation, to inflammatory mediators.

Clinical trials. The efficacy of Differin cream has been assessed in 2 randomised, double blind, parallel comparison clinical trials. In the first trial, subjects with acne vulgaris associated with at least 20 facial noninflammatory comedones and 10 inflammatory lesions were enrolled for treatment with Differin cream or the cream vehicle administered once daily.

In the second trial, subjects with acne vulgaris were enrolled for treatment with Differin cream or tretinoin cream 0. In clinical trials adapalene was seldom detected in plasma, and then only in trace amounts following chronic topical application with an analytical limit of quantification of 0.

After administration of 14 C-adapalene to rats, rabbits and dogs, radioactivity was distributed in several tissues, the highest levels being found in liver, spleen, adrenals and ovaries.

Metabolism in animals is maintained by O-demethylation, hydroxylation and conjugation, and excretion is primarily by the biliary route. In a human study performed using the gel formulation in which male volunteers followed a course of exaggerated topical application, 30 g a full tube was applied all over the body each day for 7 consecutive days, the resultant circulating plasma levels were below the limit of detection 0.

There were low quantities of the parent substance in the faeces. In another study healthy volunteers used radiolabelled adapalene 0. The other 4 subjects received a single topical application of the radiolabelled product. Levels of radioactivity in all plasma, urine, faeces and skin strip samples analysed were below the limits of reliable quantification, indicating that either very little or no radioactivity was absorbed through the skin.

A further study carried out to investigate the distribution of adapalene in the adipose tissue of women after repeated daily application of adapalene gel for 3 months, found that there was no evidence of circulating adapalene in the plasma limit of detection 0. On day 90, adapalene levels in the adipose tissue were not quantifiable in 5 of the 6 volunteers limit of detection 1 nanogram. In the 6th volunteer the mean concentration at 3 sites was 1. These concentrations were no longer evident when re-evaluated at the same sites in this subject 1 month after the cessation of treatment.

Adapalene did not demonstrate mutagenic or clastogenic activity in in vitro tests with bacterial and mammalian cells and showed no clastogenic activity in mammalian cells in vitro and an in vitro test in mice.

Lifetime studies with adapalene have been completed in mice at topical doses of 0. Phaeochromocytomas were observed in the adrenal medulla of male rats dosed at 1. This finding was not observed in female rats or in mice. The relevance of the finding in male rats to the use of Differin Topical cream in acne vulgaris is not known.

Carbomer P, PEG methyl glucose sesquistearate, glycerol, squalane, methyl hydroxybenzoate, propyl hydroxybenzoate, disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide, purified water. Incompatibilities were either not assessed or not identified as part of the registration of this medicine.

It does not contain all the available information. It does not use the place of talking to your doctor or pharmacist. All medicines have risks and benefits. The product acts against the abnormal skin processes associated with acne. If it has expired or is damaged, return it to your pharmacist for disposal.

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. DIFFERIN gel contains methyl hydroxybenzoate E which may cause allergic reactions possibly delayed and propylene glycol which can cause skin irritation. Tell your doctor if you are pregnant or plan to become pregnant. Your doctor can discuss with you the risks and benefits involved. Tell your doctor if you are breast-feeding or planning to breast-feed. Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine. Ensure that the affected areas are dry before application. Ask your doctor or pharmacist if you are not sure how much to apply. They will tell you exactly how much to use for each application. Avoid the use of of oil-based makeups and creams. Cosmetic products with an abrasive, drying or peeling action may cause an extra irritant effect. Pimples and spots will be reduced only after several application of this medicine.

It may take weeks to notice an improvement and more improvement after further use. If it is almost time for your next dose, skip the dose you missed and use your next dose when you are meant to. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily. Minimise exposure to sunlight and UV lamps. Protect your skin when you are in the sun, especially between 10 am and 3 pm.

All medicines may have some unwanted side effects. Sometimes they are serious, but most of the time they are not. Your doctor has weighed the risks of using this medicine against the benefits they expect it will have for you. Do not be alarmed by this list of possible side effects. You may not experience any of them. Tell your doctor as soon as possible if you notice any of the following and they worry you:. If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor.

You may be asked to use the cream less often, or to stop using it until symptoms subside. These are very serious side effects. You may need urgent medical attention or hospitalisation. Tell your doctor if you notice anything else that is making you feel unwell. Other side effects not listed above may occur in some patients. If you have queries about any aspect of your medicine, or any questions regarding the information in this leaflet, discuss them with your doctor or pharmacist.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. It is supplied in plastic tube with a plastic cap containing 3g, 5g, 30 g and 50g of cream or 5g, 30g and 50g of gel. Excipients with known effect. Methyl hydroxybenzoate, propyl hydroxybenzoate.

For the full list of excipients see Section 6. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes. The affected areas should be dry before application. Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use.

Not to be used in patients who are hypersensitive to the active substance or any of the excipients. For external use only. Differin Topical Cream should not come into contact with the eyes, lips, mouth and mucous membranes, angles of the nose or broken skin cuts and abrasionssunburn or eczematous skin, nor should it be used in patients with severe acne involving large areas of the body. If product enters the eye, wash immediately with warm water. Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body.

Because Differin Topical cream may cause some irritation, it is possible that simultaneous use of abrasive cleansers, astringents or strong drying agents or irritant products may cause additive irritant effects.

Animal studies on compounds with a similar mode of action to adapalene have suggested that these may enhance the development of skin cancers caused by UV light. Adapalene is essentially stable to oxygen and light and is chemically nonreactive. Whilst short-term studies have shown no phototoxic to photoallergic potential of adapalene, small numbers of reactions consistent with phototoxicity were reported in clinical studies.

Efficacy and safety in the treatment of severe pustular or deep cystic acne acne conglobata have not been studied. Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed. Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied. Effects on laboratory tests. There are no known interactions with other medications which might be used topically and concurrently with Differin Topical Cream; however other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene.

Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration.

A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application. Local adverse events may persist despite cessation of therapy. No systemic reactions have been attributed to the application of the cream to date. The allergic potential of adapalene has not been established.

Side effects. Redness, dry skin, burning sensation at the site of application and scaling. Skin irritation, pruritus and sunburn. Most reactions occurred within 1 month of the initiation of therapy and were generally observed to resolve with continued use of the product or temporary adjustment of the treatment schedule. See Table 1. Postmarketing data. Differin Cream 0. The gel formulation was first marketed in France in September The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation.

Body as a whole.

Differin Gel (adapalene %) clears acne, prevents breakouts, restores skin tone, and provides prescription strength retinoid acne treatment over the. Local synthetic retinoid of the fourth generation for the treatment of acne. Active ingredient - % adapalene - a derivative of naphthoic acid;. hydrating gentle cleanser - Google Shopping Best Highlighter, Differin Gel, A guide to visiting the French capital, Paris, France in December. differine prix en tunisie differine prix pharmacie maroc differin ordonnance ou pas differine achat en ligne differin prix en france le prix. Laboratoires Vichy, France) to a fixed combination of adapalene/benzoyl peroxide daily or every other evening and a standard emollient. Differin 0. Google Scholar. Differin topical cream is not to be taken orally. Molecular weight.

Keep out of positive of children. A NOTE FROM Reserve All reasonable efforts have been made to book that ingredient listings, product images and other information for products displayed on this website are up to date, publishing and complete. We still get that you check the government listings and warnings on a month before use.

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