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Olive leaf and Prednisone drug interactions, a phase IV clinical study of FDA data - eHealthMe
It has a rich traditional history, and now present-day research and science back up its medicinal uses. Many plants that grow in unforgiving conditions contain phyto-compounds that help them survive and thrive, and to ward off infection and other disease; this happens to make the plant useful as medicine to humans.
One such class of these compounds is grouped in a family known as polyphenols. Olive leaf has potent antiviral action — studies show activity against influenza viruses, as well as herpes, rotavirus, and the family of respiratory syncytial viruses, commonly acquired by our kids 1.
The nose and mouth are the first point of contact for respiratory infections — pumps of the spray, a few times a day, can catch a virus on contact, before it has a chance to colonize. And it tastes awesome. Olive leaf has also been shown to exhibit antibacterial activity, specifically against Escherichia coli which is the leading cause of bladder infections and gut infections; Helicobacter pylori, responsible for stomach ulcers; and Staphylococcus aureus , specifically MRSA which is the antibiotic-resistant form of this pathogenic bacteria.
Very exciting, as we are all starting to come to terms with antibiotic overuse. Olive leaf may be best known for its ability to lower blood pressure, particularly in mild-to-moderate hypertension. Oleuropein also has antilipidemic activity — a fancy way of saying that it reduces lipids, including triglycerides and LDL cholesterol 3.
Antioxidant activity further benefits the heart by protecting cell membranes in our blood vessels from free radical damage 4 ; this is a major mechanism of preventing atherosclerosis — or plaque — especially in the coronary and cerebral arteries, helping to lower the risk of heart attack and ischemic stroke.
Oleuropein, and its metabolite hydroxytyrosol another potent antioxidant produced via gut microbes are at the heart of its anti-inflammatory activity. Both oleuropein and hydroxytyrosol are able to inhibit several inflammatory enzymes, such as lipoxygenases, without affecting the cyclo-oxygenase pathways 1 — in plain language, they seem to act very much like ibuprofen, but without the digestive side effects. This could mean an effective treatment for arthritis and other causes of joint pain, and an effective adjunct to protecting the cardiovascular system, the gut, and possibly the brain.
Depression and anxiety are complex mental health disorders which can be attributed to many factors; current research suggests one of those may be inflammatory processes affecting neurotransmitters and neurons.
We also know that chronic high stress is often at the root of developing depression or anxiety, seen, for example, in PTSD. One animal study showed a significant decrease in PTSD-induced anxiety behaviour, and an increase in serotonin after just 14 days of an extract of oleuropein and hydroxytyrosol 5. Another study looked at depression caused by high prednisone dosages, and saw a complete reversal of depressive behaviour when olive leaf extract was given just before the steroid 6.
Interesting what a simple, yet strong, antioxidant is able to do. Olive leaf is known to have a hypoglycemic effect, through two suggested mechanisms: a moderation of glucose-induced insulin release, and an increased uptake of glucose at the cellular level 7. In one randomized control trial of human subjects, the oral olive leaf extract significantly lowered Hemoglobin A1C, the current marker for Type 2 Diabetes 8.
And in regards to the oxidative damage we see in diabetes-related consequences, such as tissue damage to the retina and to blood vessels, olive leaf works well here too. Both oleuropein and hydroxytyrosol extracts — again through their potent antioxidant activity — are shown to reduce oxidative damage in the realm of age-related accumulation of free radicals in the brain.
Recall that oleuropein and other phenols in olive leaf are able to reduce oxidative damage at the hypothalamus. This not only affects blood pressure mechanisms but our entire endocrine system — the array of hormones in your body that control energy levels, blood sugar, the metabolic burning of food calories, weight control, resilience to stress, reproduction, water balance, and many other functions.
Antioxidant protection of endocrine tissue — like the thyroid gland for example, results in better overall metabolic balance. Oleuropein and hydroxytyrosol also show the ability to protect mitochondria 3 , at the heart of metabolic energy production. There are very few cautions with using olive leaf — however, one to keep in mind is for those who are taking blood pressure medications: Olive leaf extract is so effective for lowering blood pressure, you may find an additive effect with your medications, lowering it too much, so use some caution here.
When in doubt, check with your naturopathic physician or herbalist. And of course, always make sure you inform your medical doctor of any natural therapeutics that you are taking. Whether you prefer to take a liquid herb or a capsule, Botanica has both options available for you. Botanica Olive Leaf Complex is free of herbicides and pesticides.
It is non-GMO, dairy free, soy free, gluten free and vegan. Libyan J. Duquesnoy, E. Ekor, M. Elfiky, A. Elzagallaai, A. Blood 95 3 , — Ergoren, M. Acta Biomed. Ganjhu, R. Virusdisease 26 4 , — Gariboldi, P. Secoiridoids from Olea Europaea. Phytochemistry 25 4 , — Ghazi, A. Goldsmith, C. Antioxidants Basel 3 4 , — Gong, D. Phytother Res. Goodman, B. April 24, Goulas, V. Food Res. Granados-Principal, S. Guinda, A. Grasas y Aceites 53 4 , — Harun, N. Herbal Medicines 12 2 , — Hashem, H.
Eurasian J. Hashmi, M. Evidence-Based Complement. Hu, X. Future Virol. Ikeda, Y. Jemai, H. Jena, A. Kabrah, S. Kashyap, D. Life Sci. Khaerunnisa, S. Khalatbary, A. Iran Red Crescent Med. PubMed Abstract Google Scholar. Khan, A. Kim, K. Cel Physiol 12 , — Kim, Y.
Klok, F. Laaboudi, W. J Pharm. Lee, W. Antioxidants Basel 9 2 , Lin, L. Antiviral Natural Products and Herbal Medicines. Tradit Complement. Meirinhos, J. Leaf Cultivars. Mostafa, N. Ismail, M. El-Araby, A. Bahgat, D. Elissawy, A. Mostafa, A. Phyton-International J. Movsumov, I. Components of the Leaves ofOlea Verrucosa. Mussini, P. Triterpenes in Leaves of Olea Europaea. Phytochemistry 14 4 , Nassir, A. Olea Europaea Subsp.
NIH b. NIH a. Parums, D. Qabaha, K. Food 21 3 , — Randon, A. Raphael, T. Phytomedicine 10 , — Russo, M. Roles of Flavonoids against Coronavirus Infection. Interact , Sampangi-Ramaiah, M. PloS one 8 3 , e Santiago-Mora, R. Savournin, C. Schumacher, B. Shawky, E. RSC Adv. Silva, S. Singh, G. Soni, M. Susalit, E. Phytomedicine 18 4 , — Takeda, Y. Viruses 13 2 , Tawakul, A. Cureus 13 11 , Vardhan, S. Vezza, T. Vijayan, R. Proteins Proteom. Visioli, F. Wang, L. Wang, X.
❾-50%}Olive leaf extract prednisone
Food Chem. Bianchi, G. Surface Waxes from Olive Fruits. Phytochemistry 31 10 , — Bouaziz, M. Burja, B. Campeol, E. CDC Google Scholar. Cimato, A. Cron, R. Wien Klin Wochenschr , — Inhibition of Leukocyte 5-lipoxygenase by Phenolics from virgin Olive Oil. Derosa, G. Phytotherapy Res. Du, S. Dub, A. Leaves in Rabbits. Libyan J. Duquesnoy, E. Ekor, M. Elfiky, A. Elzagallaai, A. Blood 95 3 , — Ergoren, M. Acta Biomed. Ganjhu, R. Virusdisease 26 4 , — Gariboldi, P.
Secoiridoids from Olea Europaea. Phytochemistry 25 4 , — Ghazi, A. Goldsmith, C. Antioxidants Basel 3 4 , — Gong, D. Phytother Res. Goodman, B. April 24, Goulas, V. Food Res. Granados-Principal, S.
Guinda, A. Grasas y Aceites 53 4 , — Harun, N. Herbal Medicines 12 2 , — Hashem, H. Eurasian J. Hashmi, M. Evidence-Based Complement. Hu, X. Future Virol. Ikeda, Y. Whether you prefer to take a liquid herb or a capsule, Botanica has both options available for you. Botanica Olive Leaf Complex is free of herbicides and pesticides. It is non-GMO, dairy free, soy free, gluten free and vegan. Each dose contains We have also created highly concentrated Olive Leaf Liquid Capsule , for those who prefer to swallow a capsule over a liquid.
Shop All. Explore the collection. Oleuropein in olive and its pharmacological effects. Scientia Pharmaceutica 78 2 , Sun, W.
Oleuropein, unexpected benefits! Oncotarget, 8 11 , Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: Focus on protection against cardiovascular and metabolic diseases. Journal of Translational Medicine, 12 Olive leaf extract attenuates inflammatory activation and DNA damage in human arterial endothelial cells. Frontiers in Cardiovascular Medicine, 6, Our analysis results are available to researchers, health care professionals, patients testimonials , and software developers open API.
All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
I didn't really think much of it for some reason. This morning I took another dose I know! I called the doctor's office and they said it sounded like I was having an allergic reaction to it which I figured and to stop taking the Prednisone and the antibiotic immediately.
I really think the reaction is more to the Prednisone than the antibiotic because I'm also urinating a lot more and a lot more frequently without drinking more fluids. After doing a little reading this morning it kind of sounds like taking herbs that stimulate your immune system could cause you to have allergic reactions to medications that you're not actually allergic to. Basically you're stimulating your immune system to fight stuff off and adding something new to your system, so your hyperstimulated immune system will start fighting everything new.
Has anyone read more about this or heard of this? I may be desperate to find something other than a true drug allergy to blame this reaction on, but I REALLY don't want to be allergic to either of these medicines.
Some forums can only be seen by registered members. View detailed profile Advanced or search site with Search Forums Advanced. Hi folks, I'll try to be as brief and descriptive as possible. I hate taking prescription medications, however after having a sinus infection that wouldn't respond to home remedies nasal cleanses, olive leaf extract and grapefruit seed extract tablets, steam humidifiers, warm rice sock I've tried three different antibiotics and nothing has helped.
I didn't really think much of it for some reason. This morning I took another dose I know! I called the doctor's office and they said it sounded like I was having an allergic reaction to it which I figured and to stop taking the Prednisone and the antibiotic immediately.
I really think the reaction is more to the Prednisone than the antibiotic because I'm also urinating a lot more and a lot more frequently without drinking more fluids. After doing a little reading this morning it kind of sounds like taking herbs that stimulate your immune system could cause you to have allergic reactions to medications that you're not actually allergic to.
Basically you're stimulating your immune system to fight stuff off and adding something new to your system, so your hyperstimulated immune system will start fighting everything new. Has anyone read more about this or heard of this? I may be desperate to find something other than a true drug allergy to blame this reaction on, but I REALLY don't want to be allergic to either of these medicines.
Any thoughts? Any help or input will be greatly appreciated!!! It can be a side effect of the med alone but you should never mix herbal and scripts. Its all drugs. Its best just to take extra care to wash you hands, not touch your face and wear a mask if you really wish to.
Eat well of course too! Immune boosters can trigger allergies. Hope you feel better. Maybe have them check to see if its fungal too. I remember that happening to someone. Posting Quick Reply - Please Wait. Similar Threads Allergic reaction to BactrimAllergies, 33 replies Severe allergic reaction at Starbucks 1st timeAllergies, 41 replies How long does an allergic reaction last?
Could immune boosting herbs cause allergic reaction to medication? User Name. Remember Me. View detailed profile Advanced or search site with. Search Forums Advanced. Advertisements Hi folks, I'll try to be as brief and descriptive as possible.
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Drug interactions are reported among people who take Olive leaf and Prednisone. Common interactions include fatigue among females and cough among males. Another study looked at depression caused by high prednisone dosages, and saw a complete reversal of depressive behaviour when olive leaf. Olive leaf extract is available as a supplement. Olive tree leaves contain oleuropein, which is a polyphenol that may help prevent weight gain. In a study. Find patient medical information for olive leaf extract oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user. Of interest, an olive leaf extract enriched in equimolar Ole was more pregnancy with prednisone and/or low molecular weight heparin. Different individuals may respond to medication in different ways. Oleuropein, unexpected benefits! Oleuropein reverses repeated corticosterone-induced depressive-like behaviour in mice: Evidence of modulating effect on biogenic amines.Perfect Protein. Superfood Beverages. Liquid Herb Capsules. Olive leaves — from the olive tree, Olea europaea , first cultivated in the Mediterranean basin over years ago — show activity in all of these health applications. It has a rich traditional history, and now present-day research and science back up its medicinal uses.
Many plants that grow in unforgiving conditions contain phyto-compounds that help them survive and thrive, and to ward off infection and other disease; this happens to make the plant useful as medicine to humans. One such class of these compounds is grouped in a family known as polyphenols. Olive leaf has potent antiviral action — studies show activity against influenza viruses, as well as herpes, rotavirus, and the family of respiratory syncytial viruses, commonly acquired by our kids 1.
The nose and mouth are the first point of contact for respiratory infections — pumps of the spray, a few times a day, can catch a virus on contact, before it has a chance to colonize. And it tastes awesome. Olive leaf has also been shown to exhibit antibacterial activity, specifically against Escherichia coli which is the leading cause of bladder infections and gut infections; Helicobacter pylori, responsible for stomach ulcers; and Staphylococcus aureus , specifically MRSA which is the antibiotic-resistant form of this pathogenic bacteria.
Very exciting, as we are all starting to come to terms with antibiotic overuse. Olive leaf may be best known for its ability to lower blood pressure, particularly in mild-to-moderate hypertension. Oleuropein also has antilipidemic activity — a fancy way of saying that it reduces lipids, including triglycerides and LDL cholesterol 3.
Antioxidant activity further benefits the heart by protecting cell membranes in our blood vessels from free radical damage 4 ; this is a major mechanism of preventing atherosclerosis — or plaque — especially in the coronary and cerebral arteries, helping to lower the risk of heart attack and ischemic stroke.
Oleuropein, and its metabolite hydroxytyrosol another potent antioxidant produced via gut microbes are at the heart of its anti-inflammatory activity. Both oleuropein and hydroxytyrosol are able to inhibit several inflammatory enzymes, such as lipoxygenases, without affecting the cyclo-oxygenase pathways 1 — in plain language, they seem to act very much like ibuprofen, but without the digestive side effects.
This could mean an effective treatment for arthritis and other causes of joint pain, and an effective adjunct to protecting the cardiovascular system, the gut, and possibly the brain. Depression and anxiety are complex mental health disorders which can be attributed to many factors; current research suggests one of those may be inflammatory processes affecting neurotransmitters and neurons.
We also know that chronic high stress is often at the root of developing depression or anxiety, seen, for example, in PTSD. One animal study showed a significant decrease in PTSD-induced anxiety behaviour, and an increase in serotonin after just 14 days of an extract of oleuropein and hydroxytyrosol 5. Another study looked at depression caused by high prednisone dosages, and saw a complete reversal of depressive behaviour when olive leaf extract was given just before the steroid 6.
Interesting what a simple, yet strong, antioxidant is able to do. Olive leaf is known to have a hypoglycemic effect, through two suggested mechanisms: a moderation of glucose-induced insulin release, and an increased uptake of glucose at the cellular level 7. In one randomized control trial of human subjects, the oral olive leaf extract significantly lowered Hemoglobin A1C, the current marker for Type 2 Diabetes 8.
And in regards to the oxidative damage we see in diabetes-related consequences, such as tissue damage to the retina and to blood vessels, olive leaf works well here too. Both oleuropein and hydroxytyrosol extracts — again through their potent antioxidant activity — are shown to reduce oxidative damage in the realm of age-related accumulation of free radicals in the brain.
Recall that oleuropein and other phenols in olive leaf are able to reduce oxidative damage at the hypothalamus. This not only affects blood pressure mechanisms but our entire endocrine system — the array of hormones in your body that control energy levels, blood sugar, the metabolic burning of food calories, weight control, resilience to stress, reproduction, water balance, and many other functions.
Antioxidant protection of endocrine tissue — like the thyroid gland for example, results in better overall metabolic balance. Oleuropein and hydroxytyrosol also show the ability to protect mitochondria 3 , at the heart of metabolic energy production. There are very few cautions with using olive leaf — however, one to keep in mind is for those who are taking blood pressure medications: Olive leaf extract is so effective for lowering blood pressure, you may find an additive effect with your medications, lowering it too much, so use some caution here.
When in doubt, check with your naturopathic physician or herbalist. And of course, always make sure you inform your medical doctor of any natural therapeutics that you are taking. Whether you prefer to take a liquid herb or a capsule, Botanica has both options available for you.
Botanica Olive Leaf Complex is free of herbicides and pesticides. It is non-GMO, dairy free, soy free, gluten free and vegan. Each dose contains We have also created highly concentrated Olive Leaf Liquid Capsule , for those who prefer to swallow a capsule over a liquid. Shop All. Explore the collection. Oleuropein in olive and its pharmacological effects. Scientia Pharmaceutica 78 2 , Sun, W. Oleuropein, unexpected benefits! Oncotarget, 8 11 , Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: Focus on protection against cardiovascular and metabolic diseases.
Journal of Translational Medicine, 12 Olive leaf extract attenuates inflammatory activation and DNA damage in human arterial endothelial cells. Frontiers in Cardiovascular Medicine, 6, Lee, B. Oleuropein reduces anxiety-like responses by activating serotonergic and neuropeptide Y NPY -ergic systems in a rat model of post-traumatic stress disorder.
Animal Cells and Systems, 22 2 , Oleuropein reverses repeated corticosterone-induced depressive-like behaviour in mice: Evidence of modulating effect on biogenic amines. Scientific Reports, 10 Olive tree Olea europaea leaves: Potential beneficial effects on human health. Nutrition Reviews 76 Hypoglycemic, hypolipidemic and antiatherogenic effects of oleuropein in alloxan- induced Type 1 diabetic rats.
Asican Pacific Journal of Tropical Disease. About the Author. Learn More. Related Posts. Nutrition Health Food Inflammation Herbs. Enter to win! Sign up for a chance to win a Botanica Health bundle!
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