Prednisolone and Clexane for Natural Killer Cells?? - Assisted Conception

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Prednisolone clexane ivf success.Prednisolone and enoxaparin (clexane) therapy ('the Bondi protocol') for repeated IVF failure

Moderator: Administrator. Post Mon Mar 08, pm. Post Tue Mar 09, am. Post Tue Mar 09, pm. Post Wed Mar 10, am. Quick links. Clexane and Prednisolone Post Mon Mar 08, pm Hi Ladies, Please can you tell me when did you start and stop taking Clexane and Prednisolone on your cycle, and what were the dosages prescribed. Thanks, Maple xxx. Post Mon Mar 08, pm Hi Maple, I have got my review with George tomorrow so i might find out the answer then! I will let you know if i do. Wren xx. Twins born Started weaning off Prednisilone at 12 weeks pregnant, took a couple of weeks to come off it altogether.

This was similar for both my fresh cycle and FET. I am a DE recip, so my stimms stage only involves building the lining of womb, not ovarian stimming don't know if that makes it a shorter stimming phase than if I was going for EC, if you see what I mean Does that help at all?

I take Pred for extremely high NK cells and killing capacity, as well as thyroid antibodies. Hope you get some more answers and a protocol you are confident in. Good luck. Love Maimie xx. Post Tue Mar 09, am Thanks Maimie for the information. It's funny how the protocols vary depending on the consultant, even for similar immunological issues Clexane and Prednisolone will be started 2 days before ET.

A huge belated congratulation on your twin pregnancy but I have known for sometime as I have occasionally stalked you! Hope you are enjoying a 'relaxing' trouble-free pregnancy. Love, Maple xxx. Maple xxx. Post Tue Mar 09, pm Maple i have just written a list of what George prescribed on the 'should i see George thread'. Maimie your signature really gives me hope, many congrats on your pregnancy.

Hope your positivity is topped back up after seeing George. Roll on for that BFP and successful pregnancy! Best of Luck, Maple xxx. Sound like George has got everything covered to ensure that you have the best chance of success.

Had NKs retested and they had come down sufficiently so didn't need any more, the pred was enough to keep it under control.

Then an NK retest - levels not quite down enough so we had another a couple of weeks later for good measure. We didn't get another NK retest done they're not cheap! Thanks Wren for your congrats, too. I'm glad my signature shows how things can turnaround with the right protocol - it's such a shame that so many of us never stand a chance before the immune drugs get us back on a level playing field.

Anyway, I hope that the Pred, Clexane, Intralipids and all the other lovely pills and jabs work wonders for both you and Maple. I love to see fellow immunies get their dream after the long, hard fight. Fingers crossed you are next.

Post Wed Mar 10, am Hi Maimie, Your story is truly inspirational and you are an excellent 'mascot' for fertility immunology! Less than 6 months to go before 2 more sets of pattering feet come along to create happy chaos in your household. Enjoy the rest of your pregnancy. Take care, Maple xxx.

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Prednisolone clexane ivf success. Prednisolone and Clexane for Natural Killer Cells??

The results were quite promising. Go for it girl what do you have to lose?! This time prescribed predisinfection, aspirin, estrofem and progesterone but not folic acid.

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Assisted Conception With so many fertility treatments available now, how do you know what is best for you? Join this group. Group owners. See less. See all in Community. See all in Getting Pregnant. See all in Pregnancy. I plan on going to another as there has to be a better and safer option. I am currently taking prednisone 20mg tablets. Is this safe?

I have been married 16yrs, and we have been trying for 14yrs to conceive, been on numerous cycles of Clomid, had a couple of Hysterosalpingogram done, had my uterus and ovaries checked with ultrasound, every test an procedure I have done have all come back normal. Only explanation I have been given, unexplainable, but see nothing wrong for us to conceive. In conclusion, can I continue with taking and finishing the prednisone that I am on, and engage in intercourse with my husband?

This week I should be ovulating, according to the period diary app I use. I have been trying to conceive for 10 years now, I have pcos, I have never received any fertility treatment, nor have I ever been pregnant, that was until December when I fell pregnant whilst taking prednisone, sadly that pregnancy ended in miscarriage at 8 weeks.

I was only in Prednisone for 10 days for a chest infection so I never expected it would help me get pregnant. I have told my doctor that when I got pregnant I was on prednisone but they refuse to prescribe it me and they are well aware of my struggle to get pregnant. I have not been able to get pregnant since, no offer of help or any interest from Doctors of my fertility.

If ever there comes up any trials to help women get pregnant on prednisone then I would happily put myself forward for it. I am saving up for surrogacy but if I can get pregnant naturally by taking prednisone then I would happily go for It. Hi pagan, M Dr Devendra from India. I m a gynecologist.. I want to tell u one thing if u have got pregnant once half d battle u have won…it means there is nothing wrong in d process of fertilization and implantation..

The use of prednisone and baby aspirin and Lovenox has been a game changer for so many women with failed attempts including myself. Hi Jen, I just read your comment. Did you use all 3 prior to pregnancy — aspirin, prednisone and clovox? Did your gynecologist prescribed them? With prednisone do your remember how long you had to take it for?

My Fertility doc has put me on it after egg retrieval. If you go to a fertility doctor they will prescribe it. You can also request it for other reasons like skin conditions and allergies. Then just try to get pregnant. Also seeing a naturopath that specializes in Fertility will help. Wondering if I should go for another cycle! This time prescribed predisinfection, aspirin, estrofem and progesterone but not folic acid.

Just wondering whether it is still OK to take the pregnacare vitamin and folic acid supplements? I am on my way to Greece to have a donar egg implanted. I am on Prednisolone as well has having intralipid infusions. This is my 5 time so am hoping is all works this time. Hi Christine. Hope you get some more answers and a protocol you are confident in.

Good luck. Love Maimie xx. Post Tue Mar 09, am Thanks Maimie for the information. It's funny how the protocols vary depending on the consultant, even for similar immunological issues Clexane and Prednisolone will be started 2 days before ET. A huge belated congratulation on your twin pregnancy but I have known for sometime as I have occasionally stalked you!

Hope you are enjoying a 'relaxing' trouble-free pregnancy. Love, Maple xxx. Maple xxx. Post Tue Mar 09, pm Maple i have just written a list of what George prescribed on the 'should i see George thread'. I am going through DE transfer treatment and have been prescribed Clexane amongst other meds. I have a blood clotting deficiency meaning my blood doesnt clot quick enough so blood thinners are a big no no for me.

Due to issues ive had in the past i am reluctant to start clexane but also dont want to mess up this treatment. Hi I have done about 4 embryo transfers using DE.

In two of the transfers I got pregnant but miscarried. They suddenly just stop. This time I was on both clexane 40 and aspirin. It sounded a bit too much. I am prone to thrombophilia but not V Leiden. Also I was having really bad contraction of the uterus a week after clexane and had some sort of orange fluid leaking. After year of marriage uncontrolled relations we started to try fertilization, that took many attempts and just when my wife used Clexane she got pregnant of twins.

At some time 2 years she had a thrombophlebitis and the doctor prescribed Clexane again, and what happened? She got pregnant again, without any treatment except Clexane. After the big news I ran for a vasectomy!

I took it during my pregnancy and ended up having premature loss. Hi , My wife has 3 times miscarriage. So I want to to how many days to take both injection and is it safe and avoid miscarriage problem. Wife is 5wk pregnant.. Hi, i took clexane on my 12 weeks pf pregnancy until one day before my delivery.

Clexane due to my recurrent miscariage of 3 times. Last month tried home insemination and got a positive pregnancy result but ended in a chemical pregnancy. Done home insemenation yesterday again. Do i use clexane now to help with implantation or when a positive pregnancy result is received?

Hi, I have the same problem, 3 miscariages and now I take Clexane injection every day. Now I have 32 weeks.

Log in Sign up. Home Community Getting pregnant Assisted Conception. Prednisolone and Clexane for Natural Killer Cells?? Please tell me side effects and if successful did your baby have any adverse affects? Would love to hear your stories please x. Add a comment. Hi there, I have taken these drugs for a few of my cycles, the main side effect from the prednisolone was insomnia and also the first few days I was feeling very warm in the face, in was on 20mg from Day 1, and had to wean off them with all cycles, as it's a medication you cant just stop.

Clexane I had no side effect, of I had a bleed during my pregnancy I was advised to stop the clexane as it's a blood thinner. I have gotten pregnant on these drugs but all ended in miscarriages. So no positive outcome yet, but atleast I have gotten pregnant. I wish you all the best for your journey. Hi there I took clexane, prednisone and aspirin for most of my pregnancy. I had miscarriages prior and started the meds for possible high nk cells for my autoimmune issues.

Healthy almost 3 year old here, no delays on his milestones so far and he's pretty awesome. I was taking prednisolone 25mg, mg aspirin, 40mg clexane and a few intralipid infusions for the first 15 weeks. All worth it in the end though. Hi ladies how do they check for natural killer cells? In my case I wasn't tested, but my FS just put me on the protocol for NK cells, as she said it wouldnt hurt to be on that medication. Maybe the other ladies can answer this for you.

Hi Michtab Thanks for your reply. I am not doing IVF yet but it is definitely on the cards with 2 miscarriages. CherieG1 Original poster. I wish I would have asked about it earlier as I feel we wasted earlier IVF attempt as these cells basically attack the embryo and don't give it much chance. I actually asked my FS to test for it and she did it via endometrial scratch similar to Pap smear. Hi CherieG1 Thanks for letting me know.

I recently had a laparoscopy and had mild endometriosis removed. All the best for your IVF journey. I would ask your Dr about the testing, some might say let's do a cycle first to see if its works on just a basic ivf protocol, and some might say they are happy to go ahead and test for it, It all comes down to your Dr and yourself, what you end up deciding, but personally I would ask for the testing any possible chance of not wasting any time and money on possible failed transfers if the chance is that you do have natural killer cells.

Like I said some doctors dont even test for it and they just put you on that protocol, be abuse the medications themselves dont necessarily have many side effects to the IVF. My FS never tested me for it, but after numerous miscarriages conceived from IVF she believed my immune system was too efficient and was fighting the embryo, so she weakens my immune system with a higher dose of prednisolone, Which last year I had a failed transfer and in the April of this year I done another transfer and I got pregnant and made it to 14 weeks and miscarried for other reasons, due to getting an ecoli infection and sepsis.

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This study describes a simple and relatively safe immune therapy protocol that may improve IVF success rates in women with evidence of. The approach combines Clexane with the steroid Prednisone. Injections continue until at least 12 weeks gestation. The research suggests a 53%. Hi Ladies I will starting my 3rd IVF in a few months and have been told I have elevated NK Cells. I will be on clexane, prednioslone. This study describes a simple and relatively safe immune therapy protocol that may improve IVF success rates in women with evidence of immune. Please tell me side effects and if successful did your baby have any adverse affects? as if IVF drugs aren't bad enough and now I have found out. Posted at h, 01 August Reply Maryan…. Louisa Posted at h, 16 November Reply Hi did you take it before getting pregnant alextwin? Like any drug, there are risks involved with taking steroids. Log in Sign up. Add a comment. Hi did you stop taking your celexane in the end?

When it comes to fertility medication, some are more controversial than others. A steroid called Prednisolone, or Prednisone, is one of them. Some call it a fertility wonder drug.

Others are more sceptical. So is it worth trying or a waste of money? Prednisolone is a form of corticosteroid sometimes prescribed to fertility patients with recurrent miscarriage , elevated natural killer NK cells or implantation issues. Prednisolone is basically a synthetic hormone that helps suppress immune responses. As an anti-inflammatory and immuno-suppressant, it can treat a range of other conditions.

These include allergies, blood disorders, respiratory problems skin problems and sperm antibodies. But while Prednisolone is well regarded in general medicine, the jury is out on its tangible benefits to fertility patients.

IVF consultant Lord Winston is distinctly wary of it. Most are small-scale. An Australian study used low-dose Prednisolone alongside blood-thinner Clexane to try to suppress natural killer cells in women with recurrent miscarriages.

The results were quite promising. But the number of participants involved was minimal, making it hard to draw firm conclusions. Other studies abound. Research in found benefits in combining Prednisone and low-dose aspirin in IVF protocols, starting three months before ovulation induction. We certainly see this combination regularly in repeat FETs. And a study saw better ongoing pregnancy rates with the use of Prednisone, aspirin, and vitamins B and D.

When prescribed to female fertility patients, Prednisolone is generally used for a short period 6 to 10 weeks. Doses vary, but 5 mg a day is common. Be wary if your clinic proposes more than 25 mg daily. Prednisolone pills are normally started on embryo transfer day or a few days earlier. But you may be told to start them when you start your stimulating medication. Prednisolone is more often prescribed for donor-egg, donor-embryo and FET cycles.

If your HCG blood test is negative, your fertility medication, including Prednisolone, will be stopped. Your dosage may be tapered off in the final week. Like any drug, there are risks involved with taking steroids. Common side effects of Prednisolone include irritability, anxiety and sleep disturbance. Taking corticosteroids in pregnancy could also affect fetal growth. The question is, are the benefits worth the risk?

It could make that crucial difference or be a dead end. Unlike intralipids, with which it is often combined, Prednisolone pills are cheap. Prednisolone can affect your metabolism, increase the risk of diabetes and change your bone structure.

Talk to your fertility clinic about Prednisolone. Until a large-scale, randomised trial is carried out, its true benefits in assisted reproduction are not clear-cut. Hello , i just wondering this is right that doctor after IVF tell me to take 2 time a day prenisolone and how this tablets can effect my pregnacy? Hi Ren, just wondering how are you doing with your IVF? I was not made aware by my gynecologist that this was a steroid nor the side effects until I researched.

I plan on going to another as there has to be a better and safer option. I am currently taking prednisone 20mg tablets. Is this safe?

In conclusion, can I continue with taking and finishing the prednisone that I am on, and engage in intercourse with my husband? This week I should be ovulating, according to the period diary app I use. I have been trying to conceive for 10 years now, I have pcos, I have never received any fertility treatment, nor have I ever been pregnant, that was until December when I fell pregnant whilst taking prednisone, sadly that pregnancy ended in miscarriage at 8 weeks.

I have not been able to get pregnant since, no offer of help or any interest from Doctors of my fertility. If ever there comes up any trials to help women get pregnant on prednisone then I would happily put myself forward for it.

I am saving up for surrogacy but if I can get pregnant naturally by taking prednisone then I would happily go for It. Hi pagan, M Dr Devendra from India. I m a gynecologist..

I want to tell u one thing if u have got pregnant once half d battle u have won…it means there is nothing wrong in d process of fertilization and implantation.. The use of prednisone and baby aspirin and Lovenox has been a game changer for so many women with failed attempts including myself. Hi Jen, I just read your comment. Did you use all 3 prior to pregnancy — aspirin, prednisone and clovox? Did your gynecologist prescribed them?

With prednisone do your remember how long you had to take it for? My Fertility doc has put me on it after egg retrieval. If you go to a fertility doctor they will prescribe it.

You can also request it for other reasons like skin conditions and allergies. Then just try to get pregnant. Also seeing a naturopath that specializes in Fertility will help. Wondering if I should go for another cycle! This time prescribed predisinfection, aspirin, estrofem and progesterone but not folic acid. Just wondering whether it is still OK to take the pregnacare vitamin and folic acid supplements? I am on my way to Greece to have a donar egg implanted.

I am on Prednisolone as well has having intralipid infusions. This is my 5 time so am hoping is all works this time. Hi Christine. I was just wondering if you were successful and why you chose Greece. I am Greek by the way! He looked at my ovulation temperature charts, and put me on Prednisolone 2.

Three years later I went back on same dose and got pregnant the first month. I know that I should take two weeks more but after that should decrease 5 Mg per day said my doctor.

Hi I conceived in 3rd ivf cycle. Previously I had couple of blighted ovums, ruptured ectopic pregnancy and underwent many procedures but with no gain for 7 yrs. Plz can any 1 help me out with my confusion.

Hi sir four months ago I had a skin disease and the doctor placed me on Prednisolone for one week but I am still on it till date will it affect my bearing children. I am roughly 4 weeks prenant and my doc just did a vaginal ultrasound confirming we are having 2 babies.. However, while viewing the ultrasound she found a quite a bit of liquid away from the embryos and prescribed baby aspirin and meticorten 5mg… I googled this medicine and it says something about fetal development, basically negative comments.

I just dont know if I should take it or not… Is it safe? I am currently 5 weeks and got prescribed the same. Can you tell me if it was beneficial for you?

Hi have been taking predinisone for the last 8 years for chest infections. Have been trying to concieve but no result of pregnancy. I have my third donor egg transfer. I do not have diabetes yet thankfully. After embryo transfer, I should take Prednisone 10mg. Any guidance greatly appreciated and wishing you health, luck and happiness for the new year. My two babies were born healthy. Before them, I had eight miscarriages and I am thankful to God that this combo worked well for me.

I hope and prays it works out for you too. I feel so lost in this- Any information would be great. Thank you Maryan for replying. I will now see this as a sign! Did they affect your health at all?

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