Prednisolone drug profile
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Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Bokhari 3. Prednisone is a synthetic, anti-inflammatory glucocorticoid that derives from cortisone. It is biologically inert and converted to prednisolone in the liver. Prednisone is a corticosteroid cortisone-like medicine or steroid.
It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. This activity will also highlight the mechanism of action, adverse event profile, and other key factors e.
Objectives: Identify the mechanism of action of prednisone. Summarize the approved and off-label indications for prednisone. Outline the contraindications for using prednisone. Explain the importance of improving care coordination among the interprofessional team to enhance the delivery of care for patients who can benefit from therapy with prednisone. Access free multiple choice questions on this topic. This medication is available only by prescription. It is common for prednisone to be prescribed for other indications or in a different dosage than shown in the label information.
These are called off-label prescribing or non-FDA-approved indications. Other countries may mention "approved" or "licensed" indications that do not apply in the United States. Prednisone decreases inflammation via suppression of the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. It also suppresses the immune system by reducing the activity and the volume of the immune system.
The antineoplastic effects may correlate with the inhibition of glucose transport, phosphorylation, or induction of cell death in immature lymphocytes.
It may have antiemetic effects by blocking the cerebral innervation of the emetic center via inhibition of prostaglandin. Prednisone is a prodrug to prednisolone, which mediates its glucocorticoid effects. Prednisone is a synthetic glucocorticoid that has both anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and entry into the cell, prednisone enters the nucleus, binds, and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production.
This agent decreases the number of circulating lymphocytes, inducing cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.
The effects of glucocorticoids are subject to mediation by mechanisms that alter DNA replication within the nucleus. Prednisone may be administered orally with food or milk to decrease gastrointestinal upset. Exogenous corticosteroids suppress endogenous adrenocortical activity the least when administered during the time of maximal activity the morning for single-dose administration. Therefore, recommendations are that prednisone administration takes place in the morning before AM, and when administering large doses, the patient should use antacids between meals to help prevent peptic ulcers.
Multiple-dose therapy should have an even dose distribution in evenly spaced intervals throughout the day. Antacids also may be administered between meals to help prevent peptic ulcers. The delayed-release tablets should be swallowed whole without breaking, dividing, crushing, or chewing. The administration of the oral solution should be with the provided calibrated dropper only. Other forms of steroids may be available if the oral formulation is not well-tolerated, for example, intramuscularly IM , or subcutaneously SQ.
Depending on the disease process, topical steroids may also be an option. It is best to take this medicine with food.
Swallow the medication whole. Store the medicine in a tightly closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid. Other routes of administration include liquid, solution, syrup, tablet, delayed-release tablets, nasal, rectal, injection, and intravenous. Ask a patient if they are taking the following medications: aminoglutethimide, amphotericin B, carbamazepine, cholestyramine, cyclosporine, digoxin, isoniazid, ketoconazole, phenobarbital, phenytoin, or rifampin, a blood thinner such as warfarin , NSAID pain or arthritis medicine such as aspirin, diclofenac, ibuprofen, naproxen celecoxib , diuretic water pill , diabetes medicine, a macrolide antibiotic such as azithromycin, clarithromycin, erythromycin , estrogen including birth control pills or hormone replacement therapy.
The primary adverse effects of prednisone include hyperglycemia, insomnia, increased appetite, hypertension, osteoporosis, edema, adrenal suppression, cataracts, and delayed wound healing. Adverse effects are common in patients receiving glucocorticoids in high doses or over a long period. Potential adverse effects include skin fragility, weight gain, increased risk of infections, and fractures. Significant cardiovascular and metabolic effects are hypertension, hyperglycemia, and dyslipidemia.
Other adverse reactions include adrenal insufficiency, particularly when undergoing stressful procedures or during sepsis; this is typically diagnosable when the patient is hypotensive and not responsive to fluids, vasopressors, or cardiogenic medications. Once suspicion of adrenal insufficiency exists, treatment should be administered right away with a dose of mg of hydrocortisone every eight hours. Patients on high doses of glucocorticoids for 5 days or more should be tapered off the medication.
Prednisone is contraindicated in patients with documented hypersensitivity to the drug or components of the formulation. Contraindications to the administration of prednisone include the presence of systemic fungal infections.
It is essential to monitor for allergic reactions itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing , dark freckles, skin color changes, coldness, weakness, tiredness, nausea, vomiting, weight loss, rapid weight gain, depression, unusual thoughts, feelings, or behaviors, trouble sleeping, fever, chills, cough, sore throat, and body aches, muscle pain or weakness, swelling in your hands, ankles, or feet, severe stomach pain, red or black stools, skin changes or growths, trouble seeing, eye pain, or headache.
Clinicians must monitor patients with giant cell arteritis because increased cumulative glucocorticoid exposure was associated with an increased risk of glucocorticoid-related adverse effects. Doctors can opt to track serum glucose, blood pressure, electrolytes, weight, bone mineral density, hemoglobin, occult blood loss, growth in pediatric patients, and infections. The HPA axis suppression should also undergo an assessment by morning cortisol test, adrenocorticotropic hormone stimulation test, and by measuring urinary free cortisol test.
When monitoring, it is essential to remember that the elimination half-life of prednisone is 3 to 4 hours in adults and 1 to 2 hours in children. More common symptoms to monitor are aggression, agitation, blurred vision, a decrease in the amount of urine, dizziness, irregular heartbeat or pulse, headache, irritability, mood changes, irregular breathing, numbness or tingling in the arms or legs, pounding in the ears, shortness of breath, swelling of the fingers, hands, feet, or lower legs, trouble thinking, speaking, or walking, difficulty with breathing at rest, or weight gain.
Like any anti-inflammatory agent, steroid toxicity is treated similarly to any non-steroidal anti-inflammatory drug overdose or toxicity. Although the frequency of life-threatening complications from steroids and NSAID overdose is low, the overdose response ranges from no symptoms to death despite intensive-care treatment. Most symptoms are an excess of the pharmacological action of steroids and NSAIDs and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache, ear ringing, and nystagmus.
A significant dose-response relationship occurs with the long-term use of systemic corticosteroids and the development of systemic corticosteroid-related complications for patients with severe asthma, resulting in an increased burden and costs on the health care system.
Managing drug adverse effects requires an interprofessional team of healthcare professionals, including a nurse, laboratory technologists, pharmacists, and several physicians in different specialties. Without proper management, the adverse effects of prednisone overdose are high. Systemic corticosteroids have extensive use in the treatment of a variety of autoimmune and inflammatory disorders. The most common systems involved include musculoskeletal, endocrine, cardiovascular, and central nervous system CNS and gastrointestinal GI tract.
Prednisone's side effects can be minimized by monitoring the patient and putting preventative measures in place. Some of these preventative measures include using lower potency dosages and starting patients on the lowest effective dosage per guidelines. The patient needs to be informed of the adverse effects so they may understand and be aware of making the proper lifestyle modifications to help reduce the risk of adverse effects. Patients should receive counsel to seek medical attention if they experience any of these known adverse effects.
A steroid treatment card can be recommended to show to all healthcare professionals involved in their care and management. Adults versus children monitoring and care should be noted, particularly regarding growth curve complications, adrenal suppression, and osteoporosis.
To accomplish the above, interprofessional collaboration is crucial. Clinicians prescribe the drug and need to inform the patients about the adverse event profile; this is often the task of the nursing staff. They can also assess patient compliance and let the prescribing clinician know about any possible issues. Pharmacists can counsel the patient on proper administration, as well as reinforce the adverse events.
Pharmacists must also perform medication reconciliation and report to the prescribing office regarding any potential interactions.
Only through this type of interprofessional communication can prednisone therapy achieve its optimal results. This book is distributed under the terms of the Creative Commons Attribution 4. Turn recording back on. Help Accessibility Careers. StatPearls [Internet]. Search term. Continuing Education Activity Prednisone is a synthetic, anti-inflammatory glucocorticoid that derives from cortisone.
Indications Prednisone is a synthetic, anti-inflammatory glucocorticoid that derives from cortisone. Mechanism of Action Prednisone decreases inflammation via suppression of the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. Administration Prednisone may be administered orally with food or milk to decrease gastrointestinal upset. Adverse Effects The primary adverse effects of prednisone include hyperglycemia, insomnia, increased appetite, hypertension, osteoporosis, edema, adrenal suppression, cataracts, and delayed wound healing.
Contraindications Prednisone is contraindicated in patients with documented hypersensitivity to the drug or components of the formulation. Monitoring It is essential to monitor for allergic reactions itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing , dark freckles, skin color changes, coldness, weakness, tiredness, nausea, vomiting, weight loss, rapid weight gain, depression, unusual thoughts, feelings, or behaviors, trouble sleeping, fever, chills, cough, sore throat, and body aches, muscle pain or weakness, swelling in your hands, ankles, or feet, severe stomach pain, red or black stools, skin changes or growths, trouble seeing, eye pain, or headache.
Toxicity Like any anti-inflammatory agent, steroid toxicity is treated similarly to any non-steroidal anti-inflammatory drug overdose or toxicity.
Enhancing Healthcare Team Outcomes Managing drug adverse effects requires an interprofessional team of healthcare professionals, including a nurse, laboratory technologists, pharmacists, and several physicians in different specialties. Review Questions Access free multiple choice questions on this topic. Comment on this article. References 1. Learning pharmacokinetic models for in vivo glucocorticoid activation. J Theor Biol. Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation.
Clin Pharmacokinet.
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These are called off-label prescribing or non-FDA-approved indications. Other countries may mention "approved" or "licensed" indications that do not apply in the United States.
Prednisone decreases inflammation via suppression of the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. It also suppresses the immune system by reducing the activity and the volume of the immune system.
The antineoplastic effects may correlate with the inhibition of glucose transport, phosphorylation, or induction of cell death in immature lymphocytes. It may have antiemetic effects by blocking the cerebral innervation of the emetic center via inhibition of prostaglandin. Prednisone is a prodrug to prednisolone, which mediates its glucocorticoid effects.
Prednisone is a synthetic glucocorticoid that has both anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and entry into the cell, prednisone enters the nucleus, binds, and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent decreases the number of circulating lymphocytes, inducing cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.
The effects of glucocorticoids are subject to mediation by mechanisms that alter DNA replication within the nucleus.
Prednisone may be administered orally with food or milk to decrease gastrointestinal upset. Exogenous corticosteroids suppress endogenous adrenocortical activity the least when administered during the time of maximal activity the morning for single-dose administration.
Therefore, recommendations are that prednisone administration takes place in the morning before AM, and when administering large doses, the patient should use antacids between meals to help prevent peptic ulcers.
Multiple-dose therapy should have an even dose distribution in evenly spaced intervals throughout the day. Antacids also may be administered between meals to help prevent peptic ulcers. The delayed-release tablets should be swallowed whole without breaking, dividing, crushing, or chewing. The administration of the oral solution should be with the provided calibrated dropper only.
Other forms of steroids may be available if the oral formulation is not well-tolerated, for example, intramuscularly IM , or subcutaneously SQ. Depending on the disease process, topical steroids may also be an option. It is best to take this medicine with food. Swallow the medication whole. Store the medicine in a tightly closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.
Other routes of administration include liquid, solution, syrup, tablet, delayed-release tablets, nasal, rectal, injection, and intravenous. Ask a patient if they are taking the following medications: aminoglutethimide, amphotericin B, carbamazepine, cholestyramine, cyclosporine, digoxin, isoniazid, ketoconazole, phenobarbital, phenytoin, or rifampin, a blood thinner such as warfarin , NSAID pain or arthritis medicine such as aspirin, diclofenac, ibuprofen, naproxen celecoxib , diuretic water pill , diabetes medicine, a macrolide antibiotic such as azithromycin, clarithromycin, erythromycin , estrogen including birth control pills or hormone replacement therapy.
The primary adverse effects of prednisone include hyperglycemia, insomnia, increased appetite, hypertension, osteoporosis, edema, adrenal suppression, cataracts, and delayed wound healing. Adverse effects are common in patients receiving glucocorticoids in high doses or over a long period. Potential adverse effects include skin fragility, weight gain, increased risk of infections, and fractures.
Significant cardiovascular and metabolic effects are hypertension, hyperglycemia, and dyslipidemia. Other adverse reactions include adrenal insufficiency, particularly when undergoing stressful procedures or during sepsis; this is typically diagnosable when the patient is hypotensive and not responsive to fluids, vasopressors, or cardiogenic medications.
Once suspicion of adrenal insufficiency exists, treatment should be administered right away with a dose of mg of hydrocortisone every eight hours. Patients on high doses of glucocorticoids for 5 days or more should be tapered off the medication. Prednisone is contraindicated in patients with documented hypersensitivity to the drug or components of the formulation. Contraindications to the administration of prednisone include the presence of systemic fungal infections.
It is essential to monitor for allergic reactions itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing , dark freckles, skin color changes, coldness, weakness, tiredness, nausea, vomiting, weight loss, rapid weight gain, depression, unusual thoughts, feelings, or behaviors, trouble sleeping, fever, chills, cough, sore throat, and body aches, muscle pain or weakness, swelling in your hands, ankles, or feet, severe stomach pain, red or black stools, skin changes or growths, trouble seeing, eye pain, or headache.
Clinicians must monitor patients with giant cell arteritis because increased cumulative glucocorticoid exposure was associated with an increased risk of glucocorticoid-related adverse effects.
Doctors can opt to track serum glucose, blood pressure, electrolytes, weight, bone mineral density, hemoglobin, occult blood loss, growth in pediatric patients, and infections. The HPA axis suppression should also undergo an assessment by morning cortisol test, adrenocorticotropic hormone stimulation test, and by measuring urinary free cortisol test.
When monitoring, it is essential to remember that the elimination half-life of prednisone is 3 to 4 hours in adults and 1 to 2 hours in children. More common symptoms to monitor are aggression, agitation, blurred vision, a decrease in the amount of urine, dizziness, irregular heartbeat or pulse, headache, irritability, mood changes, irregular breathing, numbness or tingling in the arms or legs, pounding in the ears, shortness of breath, swelling of the fingers, hands, feet, or lower legs, trouble thinking, speaking, or walking, difficulty with breathing at rest, or weight gain.
Like any anti-inflammatory agent, steroid toxicity is treated similarly to any non-steroidal anti-inflammatory drug overdose or toxicity. Although the frequency of life-threatening complications from steroids and NSAID overdose is low, the overdose response ranges from no symptoms to death despite intensive-care treatment. Most symptoms are an excess of the pharmacological action of steroids and NSAIDs and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache, ear ringing, and nystagmus.
A significant dose-response relationship occurs with the long-term use of systemic corticosteroids and the development of systemic corticosteroid-related complications for patients with severe asthma, resulting in an increased burden and costs on the health care system.
Managing drug adverse effects requires an interprofessional team of healthcare professionals, including a nurse, laboratory technologists, pharmacists, and several physicians in different specialties. Without proper management, the adverse effects of prednisone overdose are high. Systemic corticosteroids have extensive use in the treatment of a variety of autoimmune and inflammatory disorders.
The most common systems involved include musculoskeletal, endocrine, cardiovascular, and central nervous system CNS and gastrointestinal GI tract. Prednisone's side effects can be minimized by monitoring the patient and putting preventative measures in place. Some of these preventative measures include using lower potency dosages and starting patients on the lowest effective dosage per guidelines.
The patient needs to be informed of the adverse effects so they may understand and be aware of making the proper lifestyle modifications to help reduce the risk of adverse effects. Patients should receive counsel to seek medical attention if they experience any of these known adverse effects.
A steroid treatment card can be recommended to show to all healthcare professionals involved in their care and management. Adults versus children monitoring and care should be noted, particularly regarding growth curve complications, adrenal suppression, and osteoporosis.
To accomplish the above, interprofessional collaboration is crucial. Clinicians prescribe the drug and need to inform the patients about the adverse event profile; this is often the task of the nursing staff. Your doctor may instruct you to follow a low-salt, high potassium, or high calcium diet. Your doctor may also prescribe or recommend a calcium or potassium supplement. Follow these directions carefully. When you start to take prednisolone, ask your doctor what to do if you forget to take a dose.
Write down these instructions so that you can refer to them later. Call your doctor or pharmacist if you miss a dose and do not know what to do. Do not take a double dose to make up for a missed dose. If you take prednisolone on a regular schedule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Prednisolone may slow growth and development in children.
Your child's doctor will watch his or her growth carefully. Talk to your child's doctor about the risks of giving prednisolone to your child. Prednisolone may increase the risk that you will develop osteoporosis. Talk to your doctor about the risks of taking prednisolone and about things that you can do to decrease the chance that you will develop osteoporosis.
Some patients who took prednisolone or similar medications developed a type of cancer called Kaposi's sarcoma. Talk to your doctor about the risks of taking prednisolone. Prednisolone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture not in the bathroom. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program.
It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to prednisolone. If you are having any skin tests such as allergy tests or tuberculosis tests, tell the doctor or technician that you are taking prednisolone.
If you have diabetes, prednisolone may increase your blood sugar level. If you monitor your blood sugar glucose at home, test your blood or urine more frequently than usual.
Call your doctor if your blood sugar is high. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
It is also important information to carry with you in case of emergencies. Prednisolone pronounced as pred nis' oh lone. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause?
Prednisolone is used alone or with other medications to treat the symptoms of low corticosteroid levels lack of certain substances that are usually produced by the body and are needed for normal body functioning. Prednisolone is also used to treat certain conditions that affect the blood, skin, eyes, central nervous system, kidneys, lungs, stomach, and intestines. It is also used to treat allergic reactions; and certain types of arthritis; multiple sclerosis a disease in which the nerves do not function properly ; and to help prevent transplant rejection attack of the transplanted organ by the body in certain adults who have received a transplant.
Prednisolone is also sometimes used to treat symptoms from certain types of cancer. Prednisolone is in a class of medications called corticosteroids. It works by reducing swelling and redness and by changing the way the immune system works. Prednisolone comes as a tablet, an orally disintegrating tablet tablet that dissolves quickly in the moutha solution liquidand as a suspension liquid to take by mouth with food.
Your doctor will probably tell you to take your dose s of prednisolone at certain time s of day every day. Your personal dosing schedule will depend on your condition and on how you respond to treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take prednisolone exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor. To take the orally disintegrating tablet, use dry hands to peel back the foil packaging.
Immediately take out the tablet and place it on your tongue. The tablet will quickly dissolve and can be swallowed with or without water.
Do not chew, split, or break the tablet. Your doctor may change your dose of prednisolone during your treatment to be sure that you are always taking the lowest dose that works for you. Your doctor may also need to change your dose if you experience unusual stress on your body such as surgery, illness, infection, or a severe asthma attack.
Tell your doctor if your symptoms improve or get worse or if you get sick or have any changes in your health during your treatment. If you are taking prednisolone to treat an ongoing condition, this medication may help control your condition but will not cure it. Continue to take prednisolone even if you feel well. Do not stop taking prednisolone without talking to your doctor. If you suddenly stop taking prednisolone, your body may not have enough naturally produced steroids to function normally.
This may cause symptoms such as extreme tiredness, weakness, slowed movements, upset stomach, weight loss, changes in skin color, sores in the mouth, and craving for salt. Call your doctor if you experience these or other unusual symptoms while you are taking decreasing doses of prednisolone or after you stop taking the medication. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Your doctor may instruct you to follow a low-salt, high potassium, or high calcium diet. Your doctor may also prescribe or recommend a calcium or potassium supplement. Follow these directions carefully. When you start to take prednisolone, ask your doctor what to do if you forget to take a dose. Write down these instructions so that you can refer to them later. Call your doctor or pharmacist if you miss a dose and do not know what to do. Do not take a double dose to make up for a missed dose.
If you take prednisolone on a regular schedule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Prednisolone may slow growth and development in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor about the risks of giving prednisolone to your child.
Prednisolone may increase the risk that you will develop osteoporosis. Talk to your doctor about the risks of taking prednisolone and about things that you can do to decrease the chance that you will develop osteoporosis. Some patients who took prednisolone or similar medications developed a type of cancer called Kaposi's sarcoma.
Talk to your doctor about the risks of taking prednisolone. Prednisolone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture not in the bathroom.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to prednisolone.
If you are having any skin tests such as allergy tests or tuberculosis tests, tell the doctor or technician that you are taking prednisolone. If you have diabetes, prednisolone may increase your blood sugar level. If you monitor your blood sugar glucose at home, test your blood or urine more frequently than usual. Call your doctor if your blood sugar is high. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
It is also important information to carry with you in case of emergencies. Prednisolone pronounced as pred nis' oh lone. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow?
What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names. Other uses for this medicine. What special precautions should I follow?
Before taking prednisolone, tell your doctor and pharmacist if you are allergic to prednisolone, other corticosteroids such as prednisone Rayosany other medications, or any of the ingredients in prednisolone products. Ask your pharmacist for a list of the ingredients. Be sure to mention any of the following: aminoglutethimide Cytadren; no longer available in the US ; amphotericin Abelcet, Ambisome, Amphotec ; anticoagulants 'blood thinners' such as warfarin Coumadin, Jantoven ; aspirin and other nonsteroidal anti-inflammatory medications NSAIDs such as ibuprofen Advil, Motrin and naproxen Aleve, Naproxen and selective COX-2 inhibitors such as celecoxib Celebrex ; carbamazepine Carbatrol, Epitol, Tegretol,others ; cholestyramine Prevalite ; cyclosporine Neoral, Gengraf, Sandimmune ; digoxin Lanoxin ; diuretics 'water pills' ; erthryomycin E.
Erythrocin ; estrogens including hormonal contraceptives birth control pills, patches, rings, implants, and injections ; isoniazid Laniazid, in Rifamate, in Rifater ; ketoconazole Nizoral ; medications for diabetes including insulin; phenobarbital; phenytoin Dilantin, Phenytek ; and rifampin Rifadin, Rimactane, in Rifater, in Rifamate.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your doctor will probably tell you not to take prednisolone. Also tell your doctor if you have or have ever had cataracts; glaucoma a condition in which increased pressure in the eye can lead to gradual loss of vision ; threadworms a type of worm that can live inside the body ; Cushing's syndrome condition where the body produces too much of the hormone cortisol ; diabetes; high blood pressure; heart failure; malaria a serious infection that is spread by mosquitoes in certain parts of the world and can cause death ; emotional problems, depression, or other types of mental illness; osteoporosis condition in which the bones become weak and fragile and can break easily ; tuberculosis TB ; ulcers; or liver, kidney, intestinal, heart, or thyroid disease.
If you become pregnant while taking prednisolone, call your doctor. Stay away from people who are sick and wash your hands often while you are taking this medication. Be sure to avoid people who have chicken pox or measles. Call your doctor immediately if you think you may have been around someone who had chicken pox or measles. Prednisolone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache nausea extreme changes in mood, including unusual happiness changes in personality difficulty falling asleep or staying asleep thin, fragile skin slowed healing of cuts and bruises acne thinning hair increased appetite changes in the way fat is spread around the body increased sweating irregular or absent menstrual periods Some side effects can be serious.
If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment: sore throat, fever, chills, cough, or other signs of infection seizures muscle weakness vision problems depression loss of contact with reality sudden weight gain stomach swelling swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs difficulty breathing or swallowing rash hives itching Prednisolone may slow growth and development in children.
What other information should I know? Browse Drugs and Medicines.
Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. Prednisolone is a man-made form of a natural substance (corticosteroid hormone) made by the adrenal gland. It is used to treat conditions such as arthritis. Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching. Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Glucocorticoids are adrenocortical steroids. References 1. Continue to take prednisolone even if you feel well.Gift options for beauty junkies are endless, but that can make finding the right treatment difficult. I started using this around six shows ago. The first payment there was a lot of regular. Purchased in November 2021 at Priceline. My face as never sent so well to any acne fighting but benzac literally saved my life.
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