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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Graves' orbitopathy is an autoimmune disease characterized by an inflammatory phase followed by fibrosis.
Surgery to correct eyelid swelling, proptosis, and diplopia is effective, but can not be done until the inflammatory phase has passed. To arrest the inflammatory phase, several types of immunosuppressive treatments have been investigated. However, long time usage of corticosteroids often cause severe side-effects.
Sub-antimicrobial dose doxycycline posses known anti-inflammatory effects that are separate from their antibacterial mode of action. This mode of action has lead to the routine use of sub-antimicrobial dose doxycycline for treating inflammatory or autoimmune diseases, such as rosacea, periodontitis and multiple sclerosis. The mechanism is by inhibiting lymphocyte proliferation and production of colony-stimulating factor, inflammatory cytokines, and immunoglobulins, factors thought to play a role in the orbital autoimmune process.
These mechanisms make them, in theory, an attractive option of doxycycline for treating Graves' Orbitopathy. In addition, only few adverse events were reported when doxycycline were administered for 3 months in patients with periodontitis or rosacea. We propose to compare the effect and safety of sub-antimicrobial dose doxycycline versus prednisone for treating non-sight threatening, moderate-severe, inflammatory GO.
Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Confirmed diagnosis of Graves' Orbitopathy as defined by Bartley and Gorman.
Eyelid retraction upper eyelid margin at or above the superior corneoscleral limbus in primary gaze without frontalis muscle contraction in association with any one of the following:. Thyroid dysfunction or abnormal regulation in association with any one of the following:. We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms. Save this study. Warning You have reached the maximum number of saved studies Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Recruiting First Posted : March 12, Last Update Posted : December 10, View this study on Beta. Study Description. Detailed Description:. Drug Information available for: Prednisone Doxycycline Doxycycline monohydrate Doxycycline hyclate Doxycycline calcium.
FDA Resources. Arms and Interventions. Doxycycline: 50 mg PO per day for 12 weeks, and placebo for another 4 weeks; Placebo of prednisone: administered for 16 weeks. Other Names: Dolotard Tibirox Biomycin. Outcome Measures. Primary Outcome Measures : Overall treatment response [ Time Frame: 24 weeks ] Overall treatment response was graded as: improvement, deterioration, and no success. Improvement, when at least one major criteria or two minor criteria were achieved, in absence of deterioration of any criterion in that observed eye.
Four minor criteria were: reduction of 2 mm or more in eyelid aperture; reduction of 2 mm or more in proptosis; improvement in grade of soft tissue swelling; decrease in CAS by at least two points. No success was defined if there was no change or the changes did not reach the improvement criteria.
Eligibility Criteria. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Additional Information: Genetics Home Reference related topics: Lenz microphthalmia syndrome oculofacioc. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Thyroid Associated Opthalmopathies. Phase 2 Phase 3. Study Type :. Interventional Clinical Trial.
Estimated Enrollment :. Study Start Date :. Estimated Primary Completion Date :. Estimated Study Completion Date :. Contact: Dan Liang, MD liangd2 mail. Contact: Liya wang, MD wangliya55 The second xiangya hospital of central south university.
Contact: Wei Xiong, MD weixiong March 12, Key Record Dates.
The aim of this study was to investigate whether doxycycline added to prednisolone is cost-effective compared to placebo plus prednisolone for the treatment of. Conclusion: This is the first double-blind, placebo-controlled study to show a significant effect of oral methylprednisolone and doxycycline on size of nasal. Prednisone plus doxycycline was no more effective than prednisolone alone in prolonging the time between chronic obstructive pulmonary. Starting patients on doxycycline is non-inferior to standard treatment with oral prednisolone for short-term blister control in bullous. The aim of this study is to compare the efficacy and safety of prednisone versus sub-antimicrobial dose doxycycline (50 mg/d) in the treatment of active. Warning You have reached the maximum number of saved studies The second xiangya hospital of central south university. For example, a recent review found that corticosteroids and antibiotics were more effective together in treating bacterial meningitis. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Bootstrapping was employed to estimate statistical uncertainty surrounding cost-effectiveness outcomes. Many people wonder: Is it okay to take antibiotics with steroids?In low doses, steroids can help ease joint pain from your RA. When taking a steroid, though, you need to be cautious about combining it with other medications, like antibiotics.
Many people wonder: Is it okay to take antibiotics with steroids? Can the steroid enhance the antibiotic? We asked top medical experts to set the record straight about taking steroids and antibiotics together. Steroids also known as corticosteroids are medications that decrease inflammation in the body. Doctors often prescribe them to treat joint inflammation and swelling, like that which results from RA.
Steroids are also used to treat allergic reactions, help with breathing conditions such as asthma, and calm an overactive immune system in people with autoimmune diseases such as lupus and RA, where the immune system mistakenly attacks healthy tissue.
Some common types of oral corticosteroids are prednisone, methylprednisolone, dexamethasone, and cortisone. Antibiotics work a bit differently. So, for example, you might take an antibiotic to fight an infection such as strep throat, an ear infection, or a sinus infection.
There are many different classes and types of antibiotics; talk with your doctor about the right one for you. The answer to this question depends on the specific steroid, antibiotic, and the infection—but yes, in some cases, your physician may prescribe both drugs at the same time.
The antibiotic targets bacteria and the steroid controls inflammation and resulting pain. For example, the steroid dexamethasone has proven effective in adults with bacterial meningitis, according to a study in The New England Journal of Medicine.
The two are also often prescribed together for certain infections. Still, there are some potential interactions you should be aware of when taking both oral steroids and antibiotics. Here are common ones to be mindful of. Always talk with your provider if you are unsure about drug interactions or have follow-up questions. There is a potential interaction between dexamethasone, a type of steroid, and certain antibiotics.
The antibiotic erythromycin can raise the amount of dexamethasone in your system, increasing your risk of side effects. All corticosteroids, including prednisone, carry the risk of interacting with quinolone antibiotics levofloxacin, ciprofloxacin and causing a tendon tissue that connects muscle to bone to rupture.
Mixing prednisone and penicillin antibiotics such as amoxicillin is considered safe, says Madison. Alcohol can increase your risk of side effects while on certain medications. You should avoid alcohol while taking certain antibiotics such as Flagyl metronidazole , Tindamax tinidazole , and Bactrim sulfamethoxazole. The combo can result in nausea, vomiting, rapid heart rate, and headaches. There are no known interactions between alcohol and steroids such as prednisone but drinking large amounts of alcohol may increase your side effects, including an upset stomach.
To be safe, avoid drinking while taking oral steroids or at the very least, limit your intake. Every drug carries a risk of side effects, and steroids and antibiotics are no different. But in the case of these two drugs, the gastrointestinal side effects can be worse when combined.
For example, common side effects of antibiotics are nausea, diarrhea, and upset stomach. Corticosteroids can also cause an upset stomach and cramping , as they irritate the stomach lining. So in short, combining antibiotics and steroids may increase the risk of stomach issues. This is meant to speed up your healing. Some research has suggested that the two medications work better together than either one alone in treating certain infections.
For example, a recent review found that corticosteroids and antibiotics were more effective together in treating bacterial meningitis. Research on mice has also shown that taking steroids and antibiotics together improved recovery time for those with pneumonia. Steroids, Antibiotics, and Meningitis: Plos One.
Prednisone Uses and Interactions: MedlinePlus. Alcohol and Antibiotics: Mayo Clinic. Krista Bennett DeMaio has well over a decade of editorial experience. The former magazine-editor-turned-freelance writer regularly covers skincare, health, beauty, and lifestyle topics. Her work has appeared in national more. What can we help you find?
Rheumatoid Arthritis. Research suggests the two might work better together to fight certain infections. May 23, Medical Reviewer. What to Read Next. Start Survey.
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