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Prednisone changes:. Prednisone causes other more complicated effects for other nutrients, which will be outlined and explained below. The nutrients will be explained in the order in which they are most affected by prednisone. Osteoporosis is the big problem when prednisone depletes calcium.
Bone loss comes from:. Bone loss may lead to osteoporosis. Here is a video of Dr. Megan explaining this to other pharmacists. Prednisone causes the greatest loss of bone density within the first months. A myth perpetuated on patient support groups is that osteoporosis is a side effect that only affects very long-term users of prednisone. For those taking it less than 2 weeks, osteoporosis is not much of a concern. But for those taking prednisone longer than 3 months , the doctors who prescribe prednisone the most, rheumatologists , recommend supplementing calcium and vitamin D.
According to new research, prednisone depletes vitamin D which also affects the balance of calcium in the body. Vitamin D helps improve calcium absorption, so whenever someone takes calcium, vitamin D should also be taken. Since prednisone affects calcium, vitamin D also needs to be supplemented alongside the depleted calcium.
We found that after two years of treatment, the bone mineral density of the lumbar spine and forearm of patients taking calcium and vitamin D therapy improved more than patients who had no treatment. English translation?
The experts say that there is evidence that taking calcium and vitamin D works to prevent bone loss caused by prednisone. Prednisone can cause the body to remove chromium through the urine. Chromium is a metal mineral which our bodies use to keep blood sugar steady.
One of the most common side effects of prednisone is hyperglycemia, or high blood sugar, and may be caused by chromium deficiency. High blood sugar can lead to diabetes and weight gain. It is important for those taking prednisone to have enough chromium.
Oral corticosteroids cause both sodium and water retention. People taking corticosteroids should talk with their doctor about whether they should restrict salt intake. In some people, treatment with corticosteroids can impair wound healing. In one study, topical or internal vitamin A improved wound healing in eight of ten patients on corticosteroid therapy. In theory, vitamin A might also reverse some of the beneficial effects of corticosteroids, but this idea has not been investigated and no reports exist of such an interaction in people taking both vitamin A and corticosteroids.
People using oral corticosteroids should consult with a doctor to determine whether improved wound healing might outweigh the theoretical risk associated with concomitant vitamin A use. Although blood levels of vitamin A appear to increase during dexamethasone therapy—most likely due to mobilization of the vitamin from its stores in the liver—evidence from animal studies has also indicated that corticosteroids can deplete vitamin A from tissues.
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The TraceGains knowledgebase does not contain every possible interaction. Learn more about TraceGains, the company. The information presented by TraceGains is for informational purposes only. It is based on scientific studies human, animal, or in vitro , clinical experience, or traditional usage as cited in each article.
The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Information expires December This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use.
Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. What Are Nutrient Interactions. Types of interactions: Beneficial Adverse Check. Replenish Depleted Nutrients Calcium Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss. Reduce Side Effects Calcium and Vitamin D Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss.
Magnesium Corticosteroid usage has been linked to a decrease in the body's magnesium levels, and some doctors have therefore suggested that magnesium supplements of daily be taken for corticosteroid courses that are more than two weeks in length. Vitamin A A medical health practitioner should be consulted before combining Vitamin A with corticosteroids until further research is undertaken, due to possible side effects.
Calcium and Vitamin D A medical health practitioner should be consulted regarding the possibilities of taking calcium and Vitamin D supplements in addition to corticosteroid usage for the treatment of corticosteroid-induced osteoporosis. Dehydroepiandrosterone DHEA Links have been made between corticosteroid use and reduced blood levels of DHEA, and some researchers have connected this in turn to corticosteroid-induced osteoporosis.
However, further research needs to be undertaken. However, the medical effects of these losses are unclear. Corticosteroids and digitalis should not be used in combination without proper medical supervision, due to possible side effects.
References : Threlkeld DS, ed. Hormones, Adrenal Cortical Steroids, Glucocorticoids. In Facts and Comparisons Drug Information. St Louis Mo: Facts and comparisons, Apr , b. Trovato A et al. Drug-nutrient interactions. Am family Phys ; [review]. Holt GA. Chicago:Precept Press,, Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis.
Adjunctive therapy to maintenance immunosuppresion. Thelkeld DS, ed. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine.
Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.
If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of this medicine might need to be changed for a short time while you have extra stress. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.
This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment.
Your doctor may want you to have your eyes checked by an ophthalmologist eye doctor. While you are being treated with prednisone, do not have any immunizations vaccines without your doctor's approval. Prednisone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent.
In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza nasal flu vaccine , poliovirus oral form , rotavirus, and rubella.
Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor.
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According to Clinical Pharmacology , folic acid loss from prednisone may lead to glossitis, which is swelling of the tongue. Folic acid is important for keeping a good mood and a healthy heart. How prednisone lowers the amount of vitamin A in the blood is unclear. Rarely, prednisone use may cause symptoms of vitamin A deficiency. Many symptoms of vitamin A deficiency overlap with prednisone side effects, so these may be related:. According to the CDC :. Be careful not to take too much Vitamin A as it can become toxic.
Similar to Vitamin A, taking prednisone can decrease the amount of vitamin C in the blood. Megan created a supplement designed especially for people taking prednisone. Melatonin , the hormone our bodies use for helping regulate our sleep-wake cycle, may be depleted by prednisone, according to new research. Never stop taking prednisone suddenly, as your body needs time to fix this disruption and start making its own cortisol again.
Prednisone also tells the body to hold onto too much sodium, or salt. The Experts : The American College of Rheumatology , the doctors who prescribe prednisone the most, created a guideline for people taking prednisone. Eating a whole food, plant-based diet with enough protein is vital for adequate nutrition while on prednisone. For more help, visit www.
A registered dietitian emailed me to let me know exactly how he often sees these complications of prednisone treatment. Read the next article in this series to understand which foods contain these vital nutrients. These 10 Nutrients You Need will help you focus your diet on the foods most likely to help you give back the nutrients depleted by prednisone.
You can even watch a video explanation if you prefer to watch instead of read! You are being redirected to our trusted and authorized Nutranize product website. The Nutranize website is designed, constructed and endorsed by Dr. Megan Milne, the Prednisone Pharmacist. Please grant us just a few seconds to get you there. This information does not replace the advice of a doctor.
Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
What Are Nutrient Interactions. Types of interactions: Beneficial Adverse Check. Replenish Depleted Nutrients Calcium Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss. Reduce Side Effects Calcium and Vitamin D Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss.
Support Medicine Horny Goat Weed According to preliminary human studies, horny goat weed offset some of the side effects of corticosteroids. Reduces Effectiveness none. Potential Negative Interaction none. Explanation Required Licorice Licorice Glycyrrhiza glabra extract was shown to decrease the elimination of prednisone in test tube studies. The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects.
For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist. Top of the page Next Section:. Previous Section: Drug Information Top of the page. All rights reserved. Search the Healthwise Knowledgebase. Help Healthwise Index. Topic Contents Drug Information. Chromium Preliminary data suggest that corticosteroid treatment increases chromium loss.
Melatonin A controlled trial found that a single dose of the synthetic corticosteroid dexamethasone suppressed production of melatonin in nine of 11 healthy volunteers. J Endrocinol Invest ; Influence of dexamethasone on nocturnal melatonin production in healthy adult subjects. J Pineal Res ; 5; Buist RA. Drug-nutrient interactions-an overview.
Intl Clin Nutr Rev ; 4 3 : [review]. Aloe Vera as a biologically active vehicle for hydrocortisone acetate. J Am Podiatric Med Assoc ; Threlkeld DS, ed. Jubiz W, Meikle AW. Alterations of glucocorticoid actions by other disease states. Drugs ; Tamura , Nishikawa T, Yamada K, et al. Effects of glycyrrhetinic acid and its derivatives on delta -alpha-and 5-beta-reductase in rat liver. Arzneim Forsch ; Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolene hemisuccinate.
Endocrinol Japan ; Junk veggie food and its impact on health Plant based diets are growing in popularity worldwide due to decades of research and mounting evidence of health A study published in October has suggested that a plant-based, soy-rich diet may alleviate menopausal symptoms with the same effectiveness as hormone replacement therapy HRT. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
To do so may increase the chance for unwanted effects. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Measure the concentrated liquid with the special oral dropper that comes with the package. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor.
You may need to slowly decrease your dose before stopping it completely. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine.
Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of this medicine might need to be changed for a short time while you have extra stress.
Prednisone steals over nine critical nutrients from the body. This nutrient depletion is responsible for many prednisone side effects. First, what is a Nutrient? Some nutrient depletion can even lead to death. Other drugs can also cause micronutrient deficiencies as well. According to Clinical Pharmacologythe most complete drug information reference available today, prednisone also depletes potassium, folic acid, and vitamins A and C.
According to International Clinical Nutrition Revieworal corticosteroids have been shown to increase urinary loss of vitamin K, vitamin C, selenium, and zinc. The nutrients depleted by prednisone may directly lead to the most common side effects of prednisone.
Read more below for an explanation for each nutrient, how prednisone nutrient depletion can lead to prednisone side effects. Suggested Read: The next article in this series, The 10 Nutrients You Need will help you focus your diet on the foods most likely to help you give back the nutrients depleted by prednisone. A list of good food to eat while on prednisone is available as a cheat sheet. Get your Nutrients You Need cheat sheet! Prednisone affects many parts of the body in several ways which lead to nutrient depletion.
Prednisone changes:. Prednisone causes other more complicated effects for other nutrients, which will be outlined and explained below. The nutrients will be explained in the order in which they are most affected by prednisone. Osteoporosis is the big problem when prednisone depletes calcium.
Bone loss comes from:. Bone loss may lead to osteoporosis. Here is a video of Dr. Megan explaining this to other pharmacists. Prednisone causes the greatest loss of bone density within the first months. A myth perpetuated on patient support groups is that osteoporosis is a side effect that only affects very long-term users of prednisone. For those taking it less than 2 weeks, osteoporosis is not much of a concern.
But for those taking prednisone longer than 3 monthsthe doctors who prescribe prednisone the most, rheumatologistsrecommend supplementing calcium and vitamin D. According to new research, prednisone depletes vitamin D which also affects the balance of calcium in the body. Vitamin D helps improve calcium absorption, so whenever someone takes calcium, vitamin D should also be taken. Since prednisone affects calcium, vitamin D also needs to be supplemented alongside the depleted calcium.
We found that after two years of treatment, the bone mineral density of the lumbar spine and forearm of patients taking calcium and vitamin D therapy improved more than patients who had no treatment. English translation? The experts say that there is evidence that taking calcium and vitamin D works to prevent bone loss caused by prednisone.
Prednisone can cause the body to remove chromium through the urine. Chromium is a metal mineral which our bodies use to keep blood sugar steady. One of the most common side effects of prednisone is hyperglycemia, or high blood sugar, and may be caused by chromium deficiency. High blood sugar can lead to diabetes and weight gain. It is important for those taking prednisone to have enough chromium. Using prednisone for a long time can lead to magnesium loss in urine.
In our bodies, magnesium is related to bones, so when the body breaks down bones, the body gets rid of the magnesium. Magnesium may also help with keeping healthy blood sugar levels. When a person takes doses over 2. The HPA axis helps control zinc levels, so when someone takes prednisone, zinc levels can fall.
Prednisone interferes with the normal balance of electrolytes sodium, potassium, and other salts in the body, causing too much potassium to be removed in the urine.
High blood pressure is another complication and is found 4 times as often in people taking prednisone than not taking prednisone. While on prednisone, limit your sodium intake and try to eat foods high in potassium.
MedlinePlusa publication of the U. National Library of Medicine, stated the following about special dietary instructions for people taking prednisone:. Your doctor may also prescribe or recommend a calcium or potassium supplement. Prednisone may cause a loss of folic acid, but the mechanism is not clear. According to Clinical Pharmacologyfolic acid loss from prednisone may lead to glossitis, which is swelling of the tongue. Folic acid is important for keeping a good mood and a healthy heart.
How prednisone lowers the amount of vitamin A in the blood is unclear. Rarely, prednisone use may cause symptoms of vitamin A deficiency. Many symptoms of vitamin A deficiency overlap with prednisone side effects, so these may be related:.
According to the CDC :. Be careful not to take too much Vitamin A as it can become toxic. Similar to Vitamin A, taking prednisone can decrease the amount of vitamin C in the blood. Megan created a supplement designed especially for people taking prednisone. Melatoninthe hormone our bodies use for helping regulate our sleep-wake cycle, may be depleted by prednisone, according to new research.
Never stop taking prednisone suddenly, as your body needs time to fix this disruption and start making its own cortisol again. Prednisone also tells the body to hold onto too much sodium, or salt.
The Experts : The American College of Rheumatologythe doctors who prescribe prednisone the most, created a guideline for people taking prednisone. Eating a whole food, plant-based diet with enough protein is vital for adequate nutrition while on prednisone. For more help, visit www. A registered dietitian emailed me to let me know exactly how he often sees these complications of prednisone treatment. Read the next article in this series to understand which foods contain these vital nutrients.
These 10 Nutrients You Need will help you focus your diet on the foods most likely to help you give back the nutrients depleted by prednisone. You can even watch a video explanation if you prefer to watch instead of read! You are being redirected to our trusted and authorized Nutranize product website. The Nutranize website is designed, constructed and endorsed by Dr. Megan Milne, the Prednisone Pharmacist. Please grant us just a few seconds to get you there.
What is Nutrient Depletion? Nutrients, also called micronutrientsare vitamins or minerals that your body needs to eat to live. Common nutrients include calcium mineral and vitamin D vitamin. So what is Depletion? Depletion is the emptying of an important substance. When you drive, you deplete your gas tank of gasoline. When you spend money, you deplete your bank account. Without nutrients, deficiencies occur and people can suffer diseases like: Osteoporosis lack of calcium Rickets lack of vitamin D Pellagra lack of niacin Scurvy lack of vitamin C.
Which Nutrients does Prednisone Deplete? Watch Dr. Is prednisone making you miserable, too? Find Replenishment Dr. What else does prednisone change? What can I do? Megan A registered dietitian emailed me to let me know exactly how he often sees these complications of prednisone treatment. Magnesium for Myasthenia Gravis People on prednisone who have MG myasthenia gravis have been told to avoid magnesium. Because there Prednisone for Myasthenia Gravis Prednisone is prescribed for more diseases and conditions than any other drug.
Crazy, huh? Megan reacts to different prednisone meme that we found and shared online. Check out You are being taken to my store.
Corticosteroids may increase the body's loss of magnesium. Some doctors recommend that people taking corticosteroids for more than two weeks supplement with A Minor Drug Interaction exists between Mag-Oxide and prednisone. predniSONE magnesium oxide. Applies to: prednisone and Mag-Oxide (magnesium oxide). We conclude that while vitamin C supplements may have modest corticosteroid sparing effects and hence the potential to reduce exposure to their side effects. A Minor Drug Interaction exists between Mag-Oxide and prednisone. predniSONE magnesium oxide. Applies to: prednisone and Mag-Oxide (magnesium oxide). Keywords: Corticosteroid, Magnesium, Muscle atrophy Dyslipoproteinemia in systemic lupus erythematosus: effect of corticosteroids. Potassium Oral corticosteroids increase the urinary loss of potassium. What Are Nutrient Interactions. According to Clinical Pharmacologyfolic acid loss from prednisone may lead to glossitis, which is swelling of the tongue. Please read the disclaimer about the limitations of the information provided here. Some nutrient depletion can even lead to death. Austral NZJ Med ;Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss. Doctors can measure levels of activated vitamin D called 1,25 dihydroxycholecalciferol to determine whether a deficiency exists; if so, activated vitamin D is only available by prescription. A study of rheumatoid arthritis patients treated with low amounts of prednisone found that those who received 1, mg of calcium per day plus IU of vitamin D per day for two years experienced no bone loss during that time period.
An analysis of properly conducted trials concluded that supplementation with vitamin D and calcium was more effective than placebo or calcium alone in protecting against corticosteroid-induced osteoporosis. Most doctors recommend 1, mg of calcium and — IU vitamin D per day for the prevention of osteoporosis. Preliminary data suggest that corticosteroid treatment increases chromium loss.
Double-blind trials are needed to confirm these observations. A controlled trial found that a single dose of the synthetic corticosteroid dexamethasone suppressed production of melatonin in nine of 11 healthy volunteers. Further research is needed to determine if long-term use of corticosteroids interferes in a meaningful way with melatonin production, and whether supplemental melatonin would be advisable for people taking corticosteroids.
Oral corticosteroids increase the urinary loss of potassium. This may not cause a significant problem for most people. Individuals who wish to increase potassium intake should eat more fruits, vegetables, and juices rather than taking over-the-counter potassium supplements, which do not contain significant amounts of potassium.
Oral corticosteroids have been found to increase urinary loss of vitamin K , vitamin C , selenium , and zinc. The importance of these losses is unknown. Corticosteroids may increase the loss of vitamin B6. One double-blind study of people with asthma failed to show any added benefit from taking mg per day of vitamin B6 along with inhaled steroids. Therefore, while small amounts of vitamin B6 may be needed to prevent deficiency, large amounts may not provide added benefit. Some doctors recommend that people taking corticosteroids for longer than two weeks supplement with at least 2 mg of vitamin B6 per day.
Propoxyphene may cause gastrointestinal GI upset. Propoxyphene-containing products may be taken with food to reduce or prevent GI upset. A common side effect of narcotic analgesics is constipation. Increasing dietary fiber especially vegetables and whole-grain foods and water intake can ease constipation. Preliminary data suggest that supplementation with chromium mcg per day in the form of chromium picolinate may prevent corticosteroid-induced diabetes.
According to preliminary human studies, horny goat weed offset some of the side effects of corticosteroids. One preliminary study found that in people with fibrosing alveolitis a rare lung disease , supplementation with mg N-acetyl cysteine three times per day increased the effectiveness of prednisone therapy.
Licorice Glycyrrhiza glabra extract was shown to decrease the elimination of prednisone in test tube studies. If this action happens in people, it might prolong prednisone activity and possibly increase prednisone-related side effects. A small, controlled study found that intravenous iv glycyrrhizin an active constituent in licorice given with iv prednisolone prolonged prednisolone action in healthy men.
Whether this effect would occur with oral corticosteroids and licorice supplements is unknown. An animal study has shown that glycyrrhizin prevents the immune-suppressing actions of cortisone—the natural corticosteroid hormone produced by the body.
More research is necessary to determine if this action is significant in humans taking oral corticosteroids. Until more is known, people should not take licorice with corticosteroids without first consulting a doctor. Use of buckthorn Rhamnus catartica, Rhamnus frangula, Frangula alnus or alder buckthorn Rhamnus catartica , Rhamnus frangula , for more than ten days consecutively may cause a loss of electrolytes especially the mineral potassium.
Because corticosteroids also cause potassium loss, buckthorn or alder buckthorn should be used with caution if corticosteroids are being taken. Taking the oral corticosteroid methylprednisolone with grapefruit juice has been shown to delay the absorption and increase the blood concentration of the drug. The mechanism by which grapefruit juice increases the concentration of methylpredniolone in the blood is not known, but it is suspected that it may interfere with enzymes in the liver responsible for clearing the drug from the body.
In certain people, grapefruit juice may, therefore, enhance the effects of methylprednisolone. The combination should be avoided unless approved by the prescribing doctor. Corticosteroids may increase the body's loss of magnesium.
Some doctors recommend that people taking corticosteroids for more than two weeks supplement with — mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone. Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with oral corticosteroids in the same way that grapefruit juice does.
Oral corticosteroids cause both sodium and water retention. People taking corticosteroids should talk with their doctor about whether they should restrict salt intake.
In some people, treatment with corticosteroids can impair wound healing. In one study, topical or internal vitamin A improved wound healing in eight of ten patients on corticosteroid therapy.
In theory, vitamin A might also reverse some of the beneficial effects of corticosteroids, but this idea has not been investigated and no reports exist of such an interaction in people taking both vitamin A and corticosteroids.
People using oral corticosteroids should consult with a doctor to determine whether improved wound healing might outweigh the theoretical risk associated with concomitant vitamin A use. Although blood levels of vitamin A appear to increase during dexamethasone therapy—most likely due to mobilization of the vitamin from its stores in the liver—evidence from animal studies has also indicated that corticosteroids can deplete vitamin A from tissues.
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The TraceGains knowledgebase does not contain every possible interaction. Learn more about TraceGains, the company.
The information presented by TraceGains is for informational purposes only. It is based on scientific studies human, animal, or in vitro , clinical experience, or traditional usage as cited in each article.
The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Information expires December This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use.
Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
What Are Nutrient Interactions. Types of interactions: Beneficial Adverse Check. Replenish Depleted Nutrients Calcium Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss. Reduce Side Effects Calcium and Vitamin D Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss.
Support Medicine Horny Goat Weed According to preliminary human studies, horny goat weed offset some of the side effects of corticosteroids. Reduces Effectiveness none. Potential Negative Interaction none. Explanation Required Licorice Licorice Glycyrrhiza glabra extract was shown to decrease the elimination of prednisone in test tube studies.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table.
If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist. Top of the page Next Section:. Previous Section: Drug Information Top of the page. All rights reserved.
Search the Healthwise Knowledgebase. Help Healthwise Index. Topic Contents Drug Information. Chromium Preliminary data suggest that corticosteroid treatment increases chromium loss. Melatonin A controlled trial found that a single dose of the synthetic corticosteroid dexamethasone suppressed production of melatonin in nine of 11 healthy volunteers. Potassium Oral corticosteroids increase the urinary loss of potassium. Selenium Oral corticosteroids have been found to increase urinary loss of vitamin K , vitamin C , selenium , and zinc.
Vitamin B6 Corticosteroids may increase the loss of vitamin B6. Fiber Propoxyphene may cause gastrointestinal GI upset. Chromium Preliminary data suggest that supplementation with chromium mcg per day in the form of chromium picolinate may prevent corticosteroid-induced diabetes. N-Acetyl Cysteine One preliminary study found that in people with fibrosing alveolitis a rare lung disease , supplementation with mg N-acetyl cysteine three times per day increased the effectiveness of prednisone therapy.
Reduces Effectiveness none Potential Negative Interaction none Explanation Required Licorice Licorice Glycyrrhiza glabra extract was shown to decrease the elimination of prednisone in test tube studies.
Alder Buckthorn Use of buckthorn Rhamnus catartica, Rhamnus frangula, Frangula alnus or alder buckthorn Rhamnus catartica , Rhamnus frangula , for more than ten days consecutively may cause a loss of electrolytes especially the mineral potassium. Buckthorn Use of buckthorn Rhamnus catartica, Rhamnus frangula, Frangula alnus or alder buckthorn Rhamnus catartica , Rhamnus frangula , for more than ten days consecutively may cause a loss of electrolytes especially the mineral potassium.
Grapefruit Taking the oral corticosteroid methylprednisolone with grapefruit juice has been shown to delay the absorption and increase the blood concentration of the drug. Magnesium Corticosteroids may increase the body's loss of magnesium. Pomegranate Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. Sodium Oral corticosteroids cause both sodium and water retention.
Vitamin A In some people, treatment with corticosteroids can impair wound healing.
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