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Prednisone (Oral Route) Precautions - Mayo Clinic.
The average household teaspoon may not hold the right amount of liquid. Measure the concentrated liquid with the special oral dropper that comes with the package. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.
The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine.
Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress.
Your dose of this medicine might need to be changed for a short time while you have extra stress. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.
This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment.
Your doctor may want you to have your eyes checked by an ophthalmologist eye doctor. While you are being treated with prednisone, do not have any immunizations vaccines without your doctor's approval.
Prednisone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. We're building a better ClinicalTrials.
Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms.
Save this study. Warning You have reached the maximum number of saved studies Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government.
Read our disclaimer for details. Recruitment status was: Recruiting First Posted : March 12, Last Update Posted : December 10, View this study on Beta. Study Description. Detailed Description:. Drug Information available for: Prednisone Doxycycline Doxycycline monohydrate Doxycycline hyclate Doxycycline calcium.
FDA Resources. Arms and Interventions. Doxycycline: 50 mg PO per day for 12 weeks, and placebo for another 4 weeks; Placebo of prednisone: administered for 16 weeks.
Other Names: Dolotard Tibirox Biomycin. Outcome Measures. Primary Outcome Measures : Overall treatment response [ Time Frame: 24 weeks ] Overall treatment response was graded as: improvement, deterioration, and no success. Background: Most patients with mild to severe chronic obstructive pulmonary disease COPD experience exacerbations, which are also associated with increased healthcare costs.
Despite limited evidence of antibiotics' benefits for exacerbations in outpatients, antibiotics are frequently prescribed. The aim of this study was to investigate whether doxycycline added to prednisolone is cost-effective compared to placebo plus prednisolone for the treatment of COPD acute exacerbations.
Methods: An economic evaluation from the societal perspective was performed alongside a 2-year randomised trial in COPD patients in the Netherlands. The primary outcome was cost per quality-adjusted life year QALY.
❿Can You Take Steroids and Antibiotics Together?.
In low doses, steroids can help ease joint pain from your RA. When taking a steroid, though, you need to be cautious about combining it with other medications, like antibiotics.
Many people wonder: Is it okay to take antibiotics with steroids? Can the steroid enhance the antibiotic? We asked top medical experts to set the record straight about taking steroids and antibiotics together. Steroids also known as corticosteroids are medications that decrease inflammation in the body. Doctors often prescribe them to treat joint inflammation and swelling, like that which results from RA.
Steroids are also used to treat allergic reactions, help with breathing conditions such as asthma, and calm an overactive immune system in people with autoimmune diseases such as lupus and RA, where the immune system mistakenly attacks healthy tissue. Some common types of oral corticosteroids are prednisone, methylprednisolone, dexamethasone, and cortisone. Antibiotics work a bit differently. So, for example, you might take an antibiotic to fight an infection such as strep throat, an ear infection, or a sinus infection.
There are many different classes and types of antibiotics; talk with your doctor about the right one for you. The answer to this question depends on the specific steroid, antibiotic, and the infection—but yes, in some cases, your physician may prescribe both drugs at the same time.
The antibiotic targets bacteria and the steroid controls inflammation and resulting pain. For example, the steroid dexamethasone has proven effective in adults with bacterial meningitis, according to a study in The New England Journal of Medicine.
The two are also often prescribed together for certain infections. Still, there are some potential interactions you should be aware of when taking both oral steroids and antibiotics. Here are common ones to be mindful of. Always talk with your provider if you are unsure about drug interactions or have follow-up questions.
There is a potential interaction between dexamethasone, a type of steroid, and certain antibiotics. The antibiotic erythromycin can raise the amount of dexamethasone in your system, increasing your risk of side effects. All corticosteroids, including prednisone, carry the risk of interacting with quinolone antibiotics levofloxacin, ciprofloxacin and causing a tendon tissue that connects muscle to bone to rupture.
Mixing prednisone and penicillin antibiotics such as amoxicillin is considered safe, says Madison. Alcohol can increase your risk of side effects while on certain medications. You should avoid alcohol while taking certain antibiotics such as Flagyl metronidazole , Tindamax tinidazole , and Bactrim sulfamethoxazole. The combo can result in nausea, vomiting, rapid heart rate, and headaches. There are no known interactions between alcohol and steroids such as prednisone but drinking large amounts of alcohol may increase your side effects, including an upset stomach.
To be safe, avoid drinking while taking oral steroids or at the very least, limit your intake. Every drug carries a risk of side effects, and steroids and antibiotics are no different. But in the case of these two drugs, the gastrointestinal side effects can be worse when combined. For example, common side effects of antibiotics are nausea, diarrhea, and upset stomach.
Corticosteroids can also cause an upset stomach and cramping , as they irritate the stomach lining. So in short, combining antibiotics and steroids may increase the risk of stomach issues. This is meant to speed up your healing. Some research has suggested that the two medications work better together than either one alone in treating certain infections. For example, a recent review found that corticosteroids and antibiotics were more effective together in treating bacterial meningitis.
Research on mice has also shown that taking steroids and antibiotics together improved recovery time for those with pneumonia. Steroids, Antibiotics, and Meningitis: Plos One. Prednisone Uses and Interactions: MedlinePlus. Alcohol and Antibiotics: Mayo Clinic. Krista Bennett DeMaio has well over a decade of editorial experience.
The former magazine-editor-turned-freelance writer regularly covers skincare, health, beauty, and lifestyle topics. Her work has appeared in national more.
What can we help you find? Rheumatoid Arthritis. Research suggests the two might work better together to fight certain infections. May 23, Medical Reviewer. What to Read Next. Start Survey.
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However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving prednisone. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.
Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine.
Make sure you tell your doctor if you have any other medical problems, especially:. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.
The average household teaspoon may not hold the right amount of liquid. Measure the concentrated liquid with the special oral dropper that comes with the package. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. The sensitivity analysis showed similar results from the healthcare system perspective. Conclusions: In patients with mild to severe COPD treated for exacerbations in an outpatient setting, doxycycline added to prednisolone is not cost-effective compared to prednisolone plus placebo over a 2-year period.
Abstract Background: Most patients with mild to severe chronic obstructive pulmonary disease COPD experience exacerbations, which are also associated with increased healthcare costs. Graves' orbitopathy is an autoimmune disease characterized by an inflammatory phase followed by fibrosis. Surgery to correct eyelid swelling, proptosis, and diplopia is effective, but can not be done until the inflammatory phase has passed. To arrest the inflammatory phase, several types of immunosuppressive treatments have been investigated.
However, long time usage of corticosteroids often cause severe side-effects. Sub-antimicrobial dose doxycycline posses known anti-inflammatory effects that are separate from their antibacterial mode of action. This mode of action has lead to the routine use of sub-antimicrobial dose doxycycline for treating inflammatory or autoimmune diseases, such as rosacea, periodontitis and multiple sclerosis. The mechanism is by inhibiting lymphocyte proliferation and production of colony-stimulating factor, inflammatory cytokines, and immunoglobulins, factors thought to play a role in the orbital autoimmune process.
These mechanisms make them, in theory, an attractive option of doxycycline for treating Graves' Orbitopathy. In addition, only few adverse events were reported when doxycycline were administered for 3 months in patients with periodontitis or rosacea. We propose to compare the effect and safety of sub-antimicrobial dose doxycycline versus prednisone for treating non-sight threatening, moderate-severe, inflammatory GO.
Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies. Confirmed diagnosis of Graves' Orbitopathy as defined by Bartley and Gorman. Eyelid retraction upper eyelid margin at or above the superior corneoscleral limbus in primary gaze without frontalis muscle contraction in association with any one of the following:. In low doses, steroids can help ease joint pain from your RA.
When taking a steroid, though, you need to be cautious about combining it with other medications, like antibiotics. Many people wonder: Is it okay to take antibiotics with steroids? Can the steroid enhance the antibiotic? We asked top medical experts to set the record straight about taking steroids and antibiotics together.
Steroids also known as corticosteroids are medications that decrease inflammation in the body. Doctors often prescribe them to treat joint inflammation and swelling, like that which results from RA. Steroids are also used to treat allergic reactions, help with breathing conditions such as asthma, and calm an overactive immune system in people with autoimmune diseases such as lupus and RA, where the immune system mistakenly attacks healthy tissue.
Some common types of oral corticosteroids are prednisone, methylprednisolone, dexamethasone, and cortisone. Antibiotics work a bit differently. So, for example, you might take an antibiotic to fight an infection such as strep throat, an ear infection, or a sinus infection. There are many different classes and types of antibiotics; talk with your doctor about the right one for you.
Study record managers: refer to the Data Element Definitions if submitting registration or results information. Graves' orbitopathy is an autoimmune disease characterized by an inflammatory phase followed by fibrosis. Surgery to correct eyelid swelling, proptosis, and diplopia is effective, but can not be done until the inflammatory phase has passed. To arrest the inflammatory phase, several types of immunosuppressive treatments have been investigated. However, long time usage of corticosteroids often cause severe side-effects.
Sub-antimicrobial dose doxycycline posses known anti-inflammatory effects that are separate from their antibacterial mode of action. This mode of action has lead to the routine use of sub-antimicrobial dose doxycycline for treating inflammatory or autoimmune diseases, such as rosacea, periodontitis and multiple sclerosis.
The mechanism is by inhibiting lymphocyte proliferation and production of colony-stimulating factor, inflammatory cytokines, and immunoglobulins, factors thought to play a role in the orbital autoimmune process.
These mechanisms make them, in theory, an attractive option of doxycycline for treating Graves' Orbitopathy. In addition, only few adverse events were reported when doxycycline were administered for 3 months in patients with periodontitis or rosacea. We propose to compare the effect and safety of sub-antimicrobial dose doxycycline versus prednisone for treating non-sight threatening, moderate-severe, inflammatory GO.
Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies. Confirmed diagnosis of Graves' Orbitopathy as defined by Bartley and Gorman. Eyelid retraction upper eyelid margin at or above the superior corneoscleral limbus in primary gaze without frontalis muscle contraction in association with any one of the following:.
Thyroid dysfunction or abnormal regulation in association with any one of the following:. We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms. Save this study. Warning You have reached the maximum number of saved studies Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Recruiting First Posted : March 12, Last Update Posted : December 10, View this study on Beta. Study Description.
Detailed Description:. Drug Information available for: Prednisone Doxycycline Doxycycline monohydrate Doxycycline hyclate Doxycycline calcium. FDA Resources. Arms and Interventions. Doxycycline: 50 mg PO per day for 12 weeks, and placebo for another 4 weeks; Placebo of prednisone: administered for 16 weeks.
Other Names: Dolotard Tibirox Biomycin. Outcome Measures. Primary Outcome Measures : Overall treatment response [ Time Frame: 24 weeks ] Overall treatment response was graded as: improvement, deterioration, and no success. Improvement, when at least one major criteria or two minor criteria were achieved, in absence of deterioration of any criterion in that observed eye.
Four minor criteria were: reduction of 2 mm or more in eyelid aperture; reduction of 2 mm or more in proptosis; improvement in grade of soft tissue swelling; decrease in CAS by at least two points.
No success was defined if there was no change or the changes did not reach the improvement criteria. Eligibility Criteria. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Additional Information: Genetics Home Reference related topics: Lenz microphthalmia syndrome oculofacioc. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Thyroid Associated Opthalmopathies.
Phase 2 Phase 3. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Study Start Date :. Estimated Primary Completion Date :. Estimated Study Completion Date :. Contact: Dan Liang, MD liangd2 mail. Contact: Liya wang, MD wangliya55 The second xiangya hospital of central south university. Contact: Wei Xiong, MD weixiong March 12, Key Record Dates.
Comparing Doxycycline vs Prednisone ; Doxycycline has an average rating of out of 10 from a total of ratings on localhost 51% of reviewers reported a. Conclusions: In patients with mild to severe COPD treated for exacerbations in an outpatient setting, doxycycline added to prednisolone is not cost-effective. Comparing Doxycycline vs Prednisone ; Doxycycline has an average rating of out of 10 from a total of ratings on localhost 51% of reviewers reported a. Dear Dr. Roach: In late spring of , I had a sinus infection and was prescribed an antibiotic and prednisone. I was told that the steroid. NHS medicines information on possible interactions with doxycycline and other medicines, herbal remedies and supplements. A typhoid vaccine given by mouth orally may not work properly if you're taking doxycycline. There are many different classes and types of antibiotics; talk with your doctor about the right one for you. But in the case of these two drugs, the gastrointestinal side effects can be worse when combined. A single copy of these materials may be reprinted for noncommercial personal use only. Doctors often prescribe them to treat joint inflammation and swelling, like that which results from RA. The amount of medicine that you take depends on the strength of the medicine. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.Drug information provided by: IBM Micromedex. Prednisone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation swelling , severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, endocrine problems, eye or vision problems, stomach or bowel problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis.
Prednisone is a corticosteroid cortisone-like medicine or steroid. It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:.
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of prednisone in children.
However, pediatric patients are more likely to have slower growth and bone problems if prednisone is used for a long time. Recommended doses should not be exceeded, and the patient should be carefully monitored during therapy.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prednisone in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving prednisone. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
To do so may increase the chance for unwanted effects. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.
Measure the concentrated liquid with the special oral dropper that comes with the package. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor.
You may need to slowly decrease your dose before stopping it completely. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine.
Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress.
Your dose of this medicine might need to be changed for a short time while you have extra stress. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.
This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment.
Your doctor may want you to have your eyes checked by an ophthalmologist eye doctor. While you are being treated with prednisone, do not have any immunizations vaccines without your doctor's approval. Prednisone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent.
In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza nasal flu vaccine , poliovirus oral form , rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long.
If you have questions about this, talk to your doctor. This medicine may cause changes in mood or behavior for some patients.
Tell your doctor right away if you have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while taking this medicine.
This medicine might cause thinning of the bones osteoporosis or slow growth in children if used for a long time. Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. If your child is using this medicine, tell the doctor if you think your child is not growing properly.
Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain skin tests. Do not take other medicines unless they have been discussed with your doctor.
This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients.
If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
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